SERPINC1

(redirected from antithrombin-III)

SERPINC1

A gene on chromosome 1q23-q25.1 that encodes antithrombin III, a member of the serine protease inhibitor (serpin) family that rapidly inhibits thrombin, as well as other activated serine proteases of the coagulation system, and regulates the coagulation cascade.

Molecular pathology
SERPINC1 mutations cause antithrombin-III deficiency.
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References in periodicals archive ?
Inactivation of alpha-and beta- thrombin by antithrombin-III and heparin.
Key words: Antithrombin-III (AT), alanine aminotransferase (ALT), aspartate aminotransferase (AST).
Four proteins (antithrombin-III, transmembrane and immunoglobulin domain-containing protein 1, tumor protein D52, and thymidine phosphorylase) are associated with different types of cancers (p = 4.17 x [10.sup.-4] - 3.21 x [10.sup.-2]), while 2 proteins (antithrombin-III and thymidine phosphorylase) are associated with organism injury and abnormalities (p = 8.35 x [10.sup.-4] - 4.54 x [10.sup.-2]).
Thirty-four proteins in our study have been reported as constituents of the normal urine, while 11 proteins (antithrombin-III, alpha-amylase 1, U3 small nucleolar RNA-associated protein 18 homolog, thymidine phosphorylase, endonuclease domain-containing 1 protein, E3 ubiquitin-protein ligase rififylin, quinone oxidoreductase-like protein 1, interleukin enhancer-binding factor 2, transmembrane and immunoglobulin domain-containing protein 1, Ras-related protein Rab-36, and Tumor protein D52) were not reported in the normal urine proteome [7].
HS has an anticoagulant effect like heparin, by inhibiting antithrombin-III (AT III) (7, 12, 18, 19).
* Antithrombin-III. Antithrombin-III (AT-III) is a natural occurring inhibitor of blood coagulation and plays an important part in maintaining blood in the fluid state.
Fully automated antithrombin-III assays by synthetic substrate on the Multistat III.