antithrombin III deficiency


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antithrombin III deficiency

Congenital antithrombin III deficiency An AD condition characterized by ↑ risk of DVT and PE. See Antithrombin III.

antithrombin III deficiency

An inherited deficiency of certain protein-splitting enzymes (proteases) which normally participate in the blood clotting cascade sequence. Women with this deficiency are at serious risk of developing THROMBOEMBOLISM in pregnancy and HEPARIN treatment is necessary.
References in periodicals archive ?
Unfavorable genetic background increases the risk of CVT: antithrombin III deficiency, protein C, protein S, factor V or II mutation, activated protein C resistance, mutations in the methylenetetrahydrofolate reductase (MTHFR) gene.
Tsao, "Simultaneous thombosis of double coronary arteries in a young male with antithrombin III deficiency," The American Journal of Emergency Medicine, vol.
In these conditions hypercoagulable disorders including Protein C and S deficiency, Hyperhomocysteinemia, elevated levels of Factor VIII, Antithrombin III deficiency, polycythemia vera and Systemic Lupus Erythromatosus in addition to malignancy, trauma, and instrumentation are responsible for development of aortic floating thrombus [6-10].
A thorough workup for underlying thrombophilia was unrevealing including protein S and C deficiency, lupus anticoagulant, anticardiolipin antibody, Factor V Leiden mutation, ANA positivity, antithrombin III deficiency, Vitamin B12 level, homocysteine level, hemoglobin electrophoresis, and rapid plasma reagin.
Wake, "Intrapartum placement of an inferior vena cava filter for a woman with hereditary antithrombin III deficiency: its role in the prevention of fatal pulmonary embolism," The Journal of Obstetrics and Gynaecology Research, vol.
Atherosclerosis, Behcet disease, thrombocytosis, protein S, protein C, antithrombin III deficiency, and malignancies which increase thrombotic tendency can be counted among the major etiologic factors of acute mesenteric ischemia.
The etiology of thrombus formation in a macroscopically normal aorta is not well understood and has been attributed to various hypercoagulable disorders, including combined protein C and protein S deficiency, (17,10,11) elevated levels of clotting factor VIII, antithrombin III deficiency, (7) polycythemia vera, (7) essential thrombocythemia, (12) hyperhomocysteinaemia, (13) increased fibrinogen, (4) as well as autoimmune diseases with hypercoagulable states, e.g., systemic lupus erythematosus, (14) antiphospholipid syndrome, (10,11) and vasculitis.
Antithrombin III deficiency present in four patients, secondary thrombocytosis in three patients, protein C deficiency in three patients, protein S deficiency in one patient, and Factor V Leiden mutation in one patient were identified.
When GTC won regulatory approval to sell ATryn in 2009, it was after a hearing in which New Mexico lawyer Karen Janes spoke about her hope for a treatment that could help her daughter, who inherited an antithrombin III deficiency.
Initial case-control studies were suggestive of increased risk for women with inherited thrombophilias, including factor V Leiden deficiency, prothrombin gene mutation, antithrombin III deficiency, protein C deficiency, and protein S deficiency.
Differential diagnosis of DIC included microangiopathic pathologies like infectious reasons (purpura fulminans), soft tissue injury due to trauma, snake or insect venom, severe thrombotic, thrombocytopenic purpura and hemolytic uremic syndrome and hereditary thrombotic abnormalities like antithrombin III deficiency, and heterozygous PC and PS deficiency.