antithrombin


Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.
Related to antithrombin: heparin, Antithrombin deficiency

antithrombin

 [an″te-throm´bin]
any naturally occurring or therapeutically administered substance that neutralizes the action of thrombin and thus limits or restricts blood coagulation.
antithrombin I fibrin, referring to the capacity of fibrin to adsorb thrombin and thus neutralize it.
antithrombin III a naturally occurring inhibitor of blood coagulation; it is an α2-globulin member of the serpin group, synthesized in the liver and found in the plasma and various extravascular sites. It inactivates thrombin as well as certain coagulation factors and kallikrein. Inherited deficiency of the protein, an autosomal dominant disorder, is associated with recurrent deep vein thrombosis and pulmonary emboli. Complications from the disorder are prevented and, in conjunction with heparin, treated with a preparation of antithrombin III from pooled human plasma, administered intravenously.

an·ti·throm·bin

(an'tē-throm'bin),
Any substance that inhibits or prevents the effects of thrombin in such a manner that blood does not coagulate. A deficiency of antithrombin results in impaired inhibition of coagulation factors IIa, IXa, and Xa in plasma, causing recurrent thrombosis.

antithrombin

/an·ti·throm·bin/ (-throm´bin) any naturally occurring or therapeutically administered substance that neutralizes the action of thrombin and thus limits or restricts blood coagulation.
antithrombin I  fibrin, referring to its capacity to adsorb thrombin and thus neutralize it.
antithrombin III  a plasma α of the serpin family that inactivates thrombin and also inhibits certain coagulation factors and kallikrein. Inherited deficiency is associated with recurrent deep vein thrombosis and pulmonary emboli; the complications are prevented and treated with a preparation of antithrombin III from pooled human plasma.

antithrombin

[-throm′bin]
a plasma serine protease inhibitor that neutralizes thrombin. Antithrombin is a major coagulation control protein.

antithrombin

A plasma protein that diminishes the activity of THROMBIN, or the amount of thrombin produced during or following coagulation of the blood.

Antithrombin

Any substance that counters the effect of thrombin, an enzyme that converts fibrinogen into fibrin, leading to blood coagulation.

antithrombin

any naturally occurring or therapeutically administered substance that neutralizes the action of thrombin and thus limits or restricts blood coagulation.

antithrombin III (AT III)
an alpha2-globulin synthesized in the liver which is a natural inhibitor of clotting.
References in periodicals archive ?
Lotta LA, Martinelli I, Peyvandi F (2012) Prothrombin mutation conveying antithrombin resistance.
Fifty patients were included in the study which is not sufficient to establish antithrombin III as noninvasive marker in hepatitis C patients in our population of Pakistan.
The increase in antithrombin concentration during warfarin therapy in that study (2) was based on assay methods using serum and demonstrating inhibition of human thrombin.
The prevalence of hereditary antithrombin deficiency in the general population is about one in 2,000 to one in 5,000.
Two enzymatic assay principles exist for the determination of antithrombin activity, both using a chromogenic substrate.
The findings may be clinically relevant because antithrombin III seems to be more important than protein S and protein C in the overall regulation of hemostasis, she added.
1) These scaled-down versions of the traditional heparin chain have the specific pentasaccharide sequence that is necessary to bind with antithrombin.
This represents the largest known cohort of pregnant patients with HD treated with antithrombin for the prevention of VTE during a high-risk situation," Dr.
of Framingham said regulators cleared its drug ATryn, which is manufactured using milk from goats that have been scientifically altered to produce extra antithrombin,
Tokyo, Japan, July 21, 2005 - (JCNN) - Mitsubishi Pharma (TSE: 4509) announced July 20 that its overseas subsidiary Mitsubishi Pharma Europe of London received approval to market argatroban, Mitsubishi Pharma's proprietary selective antithrombin agent, as of June 1 and put it on sale on July 15.
The work-up should also include a prothrombin time/partial thromboplastin time and lupus anticoagulant profile in all of its manifestations; a measurement of protein C, S, and antithrombin III levels; a check for activated protein C resistance; as well as use of Markers of Coagulation and Hemostasis Activation (MOCHA) or your laboratory's equivalent in looking for prothrombin fragment 1.