Beta-lactam therapy for methicillin-susceptible Staphylococcus aureus bacteremia: A comparative review of cefazolin versus
antistaphylococcal penicillins.
In April 2019, the Company announced the publication of an article titled 'The
Antistaphylococcal Lysin, CF-301, Activates Key Host Factors in Human Blood to Potentiate Methicillin-Resistant Staphylococcus aureus Bacteriolysis' in the April edition of the peer-reviewed Antimicrobial Agents and Chemotherapy Journal of the American Society of Microbiology.
ContraFect announced that its manuscript titled "The
Antistaphylococcal Lysin, CF-301, Activates Key Host Factors in Human Blood To Potentiate Methicillin-Resistant Staphylococcus aureus Bacteriolysis" was published in the April edition of the peer-reviewed Antimicrobial Agents and Chemotherapy Journal of the American Society of Microbiology.
This finding circumvents any need to change current recommendations for antimicrobial drugs for TSS that include a bactericidal cell wall inhibitor (e.g., [beta]-lactamase-resistant
antistaphylococcal) and protein-synthesis inhibitor (e.g., clindamycin) along with intravenous immunoglobulin for severe cases unresponsive to first-line therapy and source control (39).
The present study was set up to evaluate the
antistaphylococcal potential of 13 Cameroonian food plants: Azadirachta indica A.
Antibacterial susceptibility testing was conducted at the Department of Bacteriology, Glasgow Royal Infirmary, Glasgow, Scotland [4], and Eurofins Microbiology Laboratories on a range of MSSA and MRSA strains and isolates with varying susceptibilities to several recognized
antistaphylococcal antibiotics.
Long-term antibiotic therapy with
antistaphylococcal activity (e.g., TMP-SMX, Penicillin, Cephalosporins) can contribute to significant reduction in skin and lung infections such that risk of developing serious future infections, pneumatoceles, and lung damage outweighs the risk of developing antibiotic resistance [4, 8, 15].
Radulovic et al., "
Antistaphylococcal activity of Inula helenium L.
Teka et al., "In vitro
antistaphylococcal effects of Embelia schimperi extracts and their component embelin with oxacillin and tetracycline," Evidence-Based Complementary and Alternative Medicine, vol.
In the study by Rajesh Kamtikar et al, [14] highest resistance was seen with penicillin and least resistance to vancomycin and linezolid and alarming resistance to the routinely used
antistaphylococcal antibiotics like erythromycin (75% - 85%), cephalosporins group (50% - 100%) and gentamicin (50% 75%).
A Cochrane review identified no benefit to routine
antistaphylococcal therapy in individuals with atopic dermatitis in the absence of clinical infection.
aureus infection in 348 NICUs, inadequate empiric antibiotic treatment (defined as not including > 1 antibiotic with
antistaphylococcal activity on day one of treatment) was associated with increased mortality among neonates with infection due to methicillin-resistant S.
