antisense strand

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Related to antisense strand: minus strand, plus strand

strand

[strand]

a thread or fiber or a structure resembling one.

antisense strand the strand of a double-stranded nucleic acid that is complementary to the sense strand; in DNA it is the template strand on which the mRNA is synthesized.

sense strand the strand of a double-stranded nucleic acid that encodes the product; in DNA it is the strand that encodes the RNA, having thus the same base sequence except changing T for U in the RNA. See also antisense strand.

an·ti·cod·ing strand

the strand of duplex DNA that is used as a template for the synthesis of mRNA.

Synonym(s): antisense strand

antisense strand

the strand of a double-stranded nucleic acid that is complementary to the sense strand, in DNA being the template strand on which the mRNA is synthesized. Compare sense strand.

non-coding strand

A strand of DNA that is not translated into a protein.

antisense strand

see ANTICODING STRAND.

antisense strand

one of the two strands in a DNA molecule that is not transcribed.

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References in periodicals archive ?

The filter for the number of A/U in the 5'-end pentamer of the antisense strand (f-AU).

Two points are gained if the 5'-end antisense strand of a siRNA sequence starts with U.

This differential stability ensures that the antisense strand is incorporated into the RISC complex, reducing the unwanted off-target effect caused by the sense-strand [10,17,19,21,24,27,28,29].

A three-phase algorithm for computer aided siRNA design

To trick a gene into making antisense RNA that complements the RNA it produces normally, biologists take advantage of the natural antisense strand that forms the quiet half of the DNA double helix.

To switch the roles of the two helix partners, researchers splice a promoter into the beginning of the sequence, then flop that piece of DNA so that the sense strand extends backward and the antisense strand extends forward.

Backward genetics: knocking some 'antisense' into wayward genes

Researchers can order primers to investigate the SNP of interest on both the sense and antisense strands as well as explore whether the template DNA is heterozygous or homozygous for a given allele.

PROLIGO DEBUTS TRUESNP PRIMER KITS BASED ON LNA

In other cases, the bound antisense strands catalyze specific chemical reactions that actively degrade the targeted mRNA.

in Woodlands, Texas, have designed antisense strands of DNA that migrate directly into the cell's nucleus.

Researchers say they have just begun to assess the behavior and safety of so-called second-and third-generation oligos -- antisense strands chemically modified for enhanced stability or therapeutic potential in the body.