antisense compound


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Related to antisense compound: Antisense therapy, antisense DNA

antisense compound

Any of the manufactured compounds that may alter disease processes by blocking the production of harmful proteins by diseased cells. These molecules seek out and impede the functioning of a diseased cell's messenger RNA (a “sense” strand). Without this intervention, the RNA would carry basic directions for the production of disease-causing proteins. Synonym: antisense drug
See also: compound
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
AVI's lead NeuGene antisense compound is designed to target cell proliferation disorders, including cardiovascular restenosis.
Early research by Isis indicated that an antisense compound would prove effective against CMV if it homed in on one of the messenger RNAs that help produce the series of proteins CMV needs for replication.
"[The c-myb gene] is one target, but there could be many other targets." He hopes to begin human clinical trials of antisense compounds within two years.
MG98 is one of the first second-generation antisense compounds to advance into Phase II clinical trials.
Hybridon owns exclusive rights to the recently issued United States Patent 6,013,786, which covers specific antisense inhibitors of human MDM2, including the MDM2 antisense compound used in the studies presented.
As we first disclosed at our Spring Bank R&D Day in December, we continue to make good progress in the advancement of our three new early research programs utilizing our small molecule nucleic acid chemistry platform, including a novel platform of STING antagonists, chiral antisense compounds against the HBx gene and next-generation RIG-I agonists for potential immuno-oncology uses.
M2 EQUITYBITES-August 2, 2012-Isis Pharmaceuticals Inc publishes encouraging new preclinical data evaluating antisense compounds to treat myotonic dystrophy type 1 (DM1)(C)2012 M2 COMMUNICATIONS http://www.m2.com