antisense DNA


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an·ti·sense DNA

the strand of DNA complementary to the one bearing the genetic message and from which it may be reconstructed; a DNA sequence complementary to a portion of mRNA; used as potential therapeutic agent to stop transcription or translation of pathogens or inappropriately expressed host gene.
References in periodicals archive ?
Under the terms of the sponsored research agreement, the company said DNAbilize antisense DNA technology will be investigated for the development of a brain cancer immunotherapy that works by activating the patient's own immune system to fight their cancer.
Rational design of point mutation-selective antisense DNA targeted to codon 12 of Ha-ras mRNA in human cells.
Targeting of antisense DNA: comparison of activity of anti-rabbit beta-globin oligodeoxyribonucleoside phosphorothioates with computer predictions of mRNA folding.
For each screened mutation, the primer was designed to anneal immediately adjacent to the nucleotide at the mutation site, on either the sense or antisense DNA strand.
On the other path, biochemists are synthesizing small pieces of antisense DNA in the laboratory that match known sequences of DNA.
Primers specific for bisulfite-converted antisense DNA were selected to amplify a region of the small nuclear ribonucleoprotein-associated polypeptide N (SNRPN) gene promoter CpG island (GenBank Accession No.
The regulation of expression of genetic information by complementary pairing of sense and antisense nucleic acid strands has been termed "antisense." It is now possible to design antisense DNA oligonucleotides or antisense RNAs that can pair with and functionally inhibit the expression of genes in a sequence fashion.
Sequencing of antisense DNA analogues by capillary gel electrophoresis with laser-induced fluorescence detection.