antisense


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to antisense: Antisense strand, Antisense drugs

strand

 [strand]
a thread or fiber or a structure resembling one.
antisense strand the strand of a double-stranded nucleic acid that is complementary to the sense strand; in DNA it is the template strand on which the mRNA is synthesized.
sense strand the strand of a double-stranded nucleic acid that encodes the product; in DNA it is the strand that encodes the RNA, having thus the same base sequence except changing T for U in the RNA. See also antisense strand.

an·ti·sense DNA

the strand of DNA complementary to the one bearing the genetic message and from which it may be reconstructed; a DNA sequence complementary to a portion of mRNA; used as potential therapeutic agent to stop transcription or translation of pathogens or inappropriately expressed host gene.

antisense

/an·ti·sense/ (an´te-) (an´ti-sens) referring to the strand of a double-stranded molecule that does not directly encode the product (the sense strand ) but is complementary to it.
Enlarge picture
Antisense strand of DNA, complementary to the sense (coding) strand and serving as a template for RNA synthesis.

antisense

(ăn′tē-sĕns′, ăn′tī-)
adj.
Of or relating to a nucleotide sequence that is complementary to a sequence of messenger RNA. When antisense DNA or RNA is added to a cell, it binds to a specific messenger RNA molecule and inactivates it.

antisense

[an′tēsens]
pertaining to a ribonucleic acid (RNA) molecule that is complementary to the messenger RNA (mRNA) produced by transcription of a given gene. Antisense RNA synthesized in the laboratory hybridizes with the complementary mRNA molecules, thereby blocking the synthesis of specific proteins. Compare sense.

gene therapy

Molecular medicine Treatment of disease by replacing, altering or supplementing the genetic structure of either germline–reproductive or somatic–nonreproductive cells a structure that is absent or abnormal and responsible for disease; any of a group of techniques in molecular biology, in which a gene of interest is manipulated, either by mutational inactivation–eg, the 'knock-out mouse', or by replacement, if it causes a particular disease; GT encompasses any therapy that specifically targets the core defect in inherited diseases, either by affecting somatic cells or germ line cells which are usually inserted into the host's genome; strategies for GT include
1. Introduction of a recombinant retrovirus with the missing gene, the promoter, and the gene regulator sequence in the 'package', and.
2. Implantation of the colonies of cells producing the missing factor(s)–eg, α1-antitrypsin deficiency with the missing enzyme introduced into 'carrier' fibroblasts
Gene therapy strategies
Antibody genes Interfere with cancer-related protein activity in tumor cells
Antisense Block synthesis of proteins encoded by a defective gene in the host
Chemoprotection Add proteins to cells that protect them from the toxic effect of chemotherapy
Immunotherapy Enhance host defense against cancer
Oncogene downregulation Turn off genes involved in uncontrolled growth and metastases of tumor cells
Suicide gene/pro-drug therapy Insert proteins that metabolize normal drugs and ↑ their toxicity to proliferating–ie tumor cells
Tumor suppressor genes Replace defective/deficient cancer-inhibiting genes
.

an·ti·sense

(an'tē-sens)
Pertaining to the strand of a double-stranded DNA or RNA molecule that is complementary to the sense strand.
References in periodicals archive ?
At the Teratology Society's annual meeting held in June at Las Croabas, Puerto Rico, Ecker reported preliminary results from a human test of an antisense drug aimed at cytomegalovirus (CMV), a type of herpesvirus that can cause a vision-threatening eye infection for AIDS patients.
AVI BioPharma develops therapeutic products for the treatment of life-threatening diseases using third-generation NEUGENE antisense drugs.
Antisense Therapeutics Limited is an Australian publicly listed biopharmaceutical drug discovery and development company.
AVI's NEUGENE antisense "rapid response therapeutics" may have a significant role to play in the future of bioterrorism defense.
The notice of allowance issued by the Canadian Intellectual Property Office is for a patent that covers basic use of antisense RNA in all cells and cellular material (eukaryotic and prokaryotic alike), and broadly covers methods for regulating gene function in all cells using antisense RNA.
Another antisense molecule, this one directed against the RNA involved in the synthesis of a growth-regulating hormone, may prove useful against chronic myelogenous leukemia, says Alan M.
AVI believes its NEUGENE antisense rapid response therapeutics will play a significant role in the future of antiviral therapeutics, including in treating emerging infectious diseases that threaten public health, or in addressing bioterrorism.
His group used the antisense technique to block the gene for an enzyme called pectin methylesterase (PME) so he could study its role in fruit softening.
He hopes to begin human clinical trials of antisense compounds within two years.
Because HCV and other single-stranded RNA viruses have relatively simple genetic structures, they are attractive targets for AVI's NEUGENE antisense, which is designed to target conserved portions of the viral genetic code that are not likely to mutate over time.
The once obscure field now boasts its own peer-reviewed scientific journal -- ANTISENSE RESEARCH AND DEVELOPMENT -- and has spawned nearly a dozen new biotechnology companies.
The first presentation, titled "Inhibition of Several Subtypes of Influenza A Virus with Antisense Morpholino Oligomers," was presented by AVI collaborators from Oregon State University and included data from collaborators at the Massachusetts Institute of Technology; the Public Health Agency of Canada in Winnipeg; and Mahidol University in Bangkok, Thailand.