Rebound acidity is a common phenomenon after cessation of antisecretory
There are several treatment options for functional dyspepsia which include antisecretory
agents, prokinetic agents, Helicobacter pylori eradication, antidepressants and psychological interventions.
Exploration of the influence of nonantimicrobial antidiarrheal agents with only antisecretory
effect, such as racecadotril, as monotherapy and in combination with AMDs would also be beneficial.
The protection to the gastric mucosa against ulceration may be because of antisecretory
and cytoprotective property of CO.
As evidence of the protective role of Hp in GERD, the following arguments are described: the development of Hp-associated gastritis in the fundus is accompanied by a decrease in the hydrochloric acid secretion (by inhibiting the production of histamine along with increased synthesis of interleukin (IL)-1[beta] and tumor necrotizing factor (TNF-a)); proximal gastritis improves the gastroesophageal junction barrier function; hypergastrinemia associated with Hp infection leads to increased pressure of the lower esophageal sphincter (LES), high urease activity of Hp partially neutralizes the aggressive action of hydrochloric acid; Hp can increase antisecretory
effect of main antisecretory
drugs--proton pump inhibitors [14, 15, 18].
activity of the extract was evidenced by significant reduction in gastric volume, acid output, and increase in gastric pH when compared to control (without extract) rats .
1982) Gastric antisecretory
, antiulcer and cytoprotective properties of 9-hydroxy-19,20-bis-norprostanoic acid in experimental animals.
While Gaviscon is effective when used alone, it is compatible with, and does not interfere with the activity of antisecretory
agents such as cimetidine.
After oral administration of PM, the onset or the antisecretory
effect of omeprazole occurs within 1 h, with the maximum effect occurring within 2 h (10).
AMITIZA is a specific activator of ClC-2 chloride channels in the intestinal epithelium and it bypasses the antisecretory
action of opiates.
Our exclusion criteria were (1) previous gastric surgery, (2) previous H pylori eradication treatment, (3) consumption of antibiotics during the previous month, and (4) consumption of antisecretory
drugs, bismuth salts, or sucralfate during the previous 2 weeks.
and antihemorrhagic activity of Azadirachta indica used to treat cholera and diarrhea in India.