Tursi reported on 3 patients with GERD refactory to antisecretory
treatment who were diagnosed with CD after duodenal biopsies and who had rapid and long lasting remission of symptoms after starting a GFD.
non-eradication therapy (with or without long-term maintenance antisecretory
therapy) for the prevention of recurrent bleeding from peptic ulcer.
Diarrhea is often treated with antispasmodic, antisecretory
, and inhibitors of prostaglandin secretions such as loperamide, diaretyl, and atropine [3, 5].
As somatostatin analogs decrease Cg A synthesis and secretion, the decreased blood measurements likely reflect antisecretory
rather than antiproliferative effects.
Effect of antisecretory
drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, antiplatelet agents, and anticoagulants.
The authors remind us that loperamide is different from antimotility agents such as diphenoxylate with atropine, as loperamide has an antisecretory
effect at lower doses and decreases motility only at higher doses.
Effects of acid antisecretory
drugs on mucus barrier of the rat against 5-fluorouracil-induced gastrointestinal mucositis.
Most cases were treated successfully with conservative treatment, such as avoiding further thermal insult (17%) and antisecretory
treatment, such as PPIs (67%) and H2RAs (11%) or in combination with sucralfate suspension (33%) to prevent further injury from reflux gastric acid.
Al Moutaery, "Studies on the antisecretory
, gastric anti-ulcer and cytoprotective properties of glycine," Research Communications in Molecular Pathology and Pharmacology, vol.
So, the antisecretory
and antimotility activities play vital roles in evaluating antidiarrheal mechanisms of drugs.
Other works demonstrated that the antisecretory
action of the aqueous extract occurs through a mechanism common to both antihistaminic and anticholinergic pathways .
Therefore we agree with authors who affirm that for obese patients suffering from GERD weight loss in conjunction with antisecretory
medications is first-line therapy .