The findings also reinforce the general strategy of treating with anabolic therapy followed by an antiresorptive
agent, rather than the other way around.
There have been reports of AFF with denosumab which is another antiresorptive
announced today that Chugai filed a new drug application to the Ministry of Health, Labour and Welfare for the oral formulation of bisphosphonate antiresorptive
agent which was co-developed by the two companies for the indication of osteoporosis.
Consider avoiding the use of an antiresorptive
agent during the drug holiday," Dr.
A position paper on Medication Related Osteonecrosis of the Jaw (MRONJ), released by the American Association of Oral and Maxillofacial Surgeons, expands the scope of the condition previously referred to as Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) and changes its name to reflect the antiresorptive
(denosumab) and antiangiogenic therapies that have recently been associated with the condition.
It is also the most widely prescribed antiresorptive
for treatment of osteoporosis globally and has been clinically studied for over 18 years.
All other treatments have antiresorptive
effects that block bone loss.
20) There have been a number of recent studies suggesting additive effects on bone mineral density when teriparatide is used with antiresorptive
drugs (bisphosphonates), atypical fractures and rebound effect: new evidence of similitude.
MINNEAPOLIS--Combining the antiresorptive
denosumab with the anabolic agent teriparatide increased bone mineral density more than either drug alone in postmenopausal women at high fracture risk in the ongoing DATA study.
In addition to blood transfusions and iron chelation therapy; hormonal replacement therapy, calcium and vitamin D supplementation; antiresorptive
drugs like bisphosphonates are used to inhibit osteoclast function.
com)-- On the heels of an earlier study linking antiresorptive
drugs to medication induced osteonecrosis of the jaw, or ONJ, researchers at the Columbia University of Dental Medicine have found that a specific genetic variation can raise the risk of this disease developing.