All patients were maintained on triple immunosuppression antirejection therapy
of a calcineurin inhibitor, or CNI, mycophenolate mofetil and prednisone.
The immunosuppressive regimens and antirejection therapy
with pulse-dose methylprednisolone used in solid organ transplantation might have been considered as the predisposing factor [8, 9].
with high doses of corticosteroids could have exerted an additional important risk factor.
These results illustrate better graft outcomes after PCAR without ABMR and suggest that the presence of multiple pathophysiological conditions, including that of ABMR, underlies the discrepancies in the effects of antirejection therapy. Therefore, in considering therapy for PCAR, we should be sure to identify these conditions and, especially, to distinguish between ABMR and non-ABMR.
More aggressive antirejection therapy might prevent the progression of IF/TA, which is important cause of allograft rejection, and might improve allograft survival in this case .
Patients receiving thymoglobulin antirejection therapy
(3 cases) were fewer in the heated versus control group (13 cases; P=.014).
In these 6 cases, therefore, the AR diagnosis was based on clinical signs and symptoms, plasma creatinine concentrations, and a satisfactory response to empirical treatment with antirejection therapy
. The staff of the Pathology Department, HUCA, evaluated all of the biopsies according to the Banff 97 classification for AR diagnosis in renal transplantation and without knowledge of the concentrations of biochemical markers obtained in the present study.
(7) In the posttransplant population, it is a well-known complication of antirejection therapy
with cyclosporin A (8-10) and tacrolimus.
WASHINGTON -- The introduction of highly active antiretroviral therapy, more effective prophylactic regimens, and improvements in surgical technique and antirejection therapy
have made solid organ transplantation a possibility for HIV-infected patients, said Marla J.
We measured the blood count of CD[4.sup.+] and CD4/D[R.sup.+]T lymphocytes in the third patient to indicate the degree of immunosuppression, since antirejection therapy
had been administered 15 months before the occurrence of PCP.
The treatment was developed at the University of Pittsburgh (PA) using the hypothesis that delivering antirejection therapy
directly into the lungs might provide greater protection for transplant recipients.
Among organ transplant recipients, salmonellosis is associated strongly with antirejection therapy
(2), and febrile illness with bacteremia is a more common presentation (3).