antipyrine


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antipyrine

 [an″te-, an″ti-pi´rēn]
a compound formerly used as an analgesic and antipyretic, now replaced by safer and more effective agents. Its current uses are as a component of multi-ingredient ear drop solutions and complexed with chloral hydrate in dichloralphenazone, a sedative and hypnotic used for headaches. Called also phenazone.

an·ti·py·rine

(an'tē-pī'rin),
An analgesic and antipyretic, no longer used systemically because of the risk of agranulocytosis. It is still used topically as an analgesic in acute otitis media and to loosen cerumen from the external auditory canal and as an analgesic following removal of cerumen.

antipyrine

/an·ti·py·rine/ (an″te-pi´rēn) an analgesic used as a component of topical solutions for decongestion and analgesia in acute otitis media. See also dichloralphenazone.

an·ti·py·rine

(an'tē-pī'rin)
An analgesic and antipyretic, used topically as an analgesic in acute otitis media and to loosen cerumen from the external auditory canal.

antipyrine (an´tēpī´rēn),

n an analgesic and antipyretic used in conjunction with salicylates.

antipyrine

References in periodicals archive ?
ii) 4-[N-(3:4-methylene dioxy benzylidene) amino] antipyrine semicarbazone:
For estimation, extraction of each sample was done with one disc only and 50 [micro]l of the extract was added to 1 ml of the commercially available enzymatic reagent kit containing cholesterol esterase, cholesterol oxidase, peroxidase, phenol and 4-amino antipyrine in PIPES buffer (Lot no.
The enzymatic reagent for cholesterol contained cholesterol esterase, cholesterol oxidase, peroxidase, phenol, and 4-amino antipyrine in PIPES buffer (4) and was purchased from RANDOX.
Previous studies have shown that PSP decreased antipyrine clearance and inhibited rat CYP2C11-mediated tolbutamide 4-hydroxylation and in human CYP2C9.
Preclinical studies conducted in animals investigated the permeation rate of NKTR-118 administered as compared to naloxone, antipyrine (a high brain permeation standard) and atenolol (a low brain permeation standard with no appreciable blood brain barrier penetration).
A large liver bank consisting of 226 biopsy specimens of similar histopathologic condition was probed for total CYP content (nmol CYP/gram liver), and antipyrine clearance was measured in vivo in the same subjects (Sotaniemi et al.
Previous studies have shown that PSP decreased antipyrine clearance and inhibited CYP2C11 -mediated tolbutamide 4-hydroxylation in the rat both in vitro and in vivo.
Antipyrine: Simvastatin had no effect on the pharmacokinetics of antipyrine.
Numerous tests of functional hepatic reserve, such as galactose elimination capacity [1], antipyrine breath test [2], and indocyanine green clearance [3], that utilize the role of the liver as an organ for detoxifying xenobiotics via the cytochrome P-450 mixed-function oxidase system, have been investigated previously although their clinical utility has been limited.
Antipyrine clearance is most accurate in the assessment of chronic liver injury [182].
Kind PRN, King EJ (1954) Estimation of plasma phosphatase by determination of hydrolysed phenol with antipyrine.