antipsychotic drug


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Related to antipsychotic drug: schizophrenia, antidepressant drug

antipsychotic drug

n.
Any of a group of drugs, such as the phenothiazines or butyrophenones, that are used to treat psychosis. Also called major tranquilizer.

antipsychotic

adjective Referring to an antipsychotic drug.

noun Any drug that attenuates psychotic episodes.
 
Agents
Phenothiazines, thioxanthenes, butyrophenones, dibenzoxazepines, dibenzodiazepines, diphenylbutylpiperidines.
 
Main types of antipsychotics
Typical and atypical, which differ in their side/adverse effects.
 
Indications
Management of schizophrenic, paranoid, schizo-affective and other psychotic disorders; acute delirium, dementia, manic episodes (during induction of lithium therapy), control of movement disorders (in Huntington’s disease), Tourette syndrome, ballismus, intractable hiccups, severe nausea and vomiting (by blocking the medulla’s chemoreceptor trigger zone).
 
Adverse effects
Extrapyramidal effects (dystonia, akathisia, parkinsonism), tardive dyskinesia due to blocking of basal ganglia; sedation and autonomic side effects (orthostatic hypotension, blurred vision, dry mouth, nasal congestion and constipation) are due to blocking of histaminic, cholinergic and adrenergic receptors.
References in periodicals archive ?
In WE-D, which is considered as a subtype of TD, abnormal movements in the neck, face, mouth, arms, and legs appear shortly after a rapid reduction of the antipsychotic drug dose or sudden discontinuation of the drug in a portion of patients who do not display abnormal involuntary movements during antipsychotic treatment.
Findings from another study using Medicaid data found that children in areas underserved by child psychiatrists are likelier to be prescribed atypical antipsychotic drugs for nonpsychotic conditions than in areas where more child psychiatrists practice.
Residents without a history of antipsychotic drug use should not receive these drugs unless necessary to treat a specific condition as diagnosed and documented in the clinical record.
Antipsychotic drugs are classed as typical, or first generation, and atypical (second generation).
They found that an enzyme called HDAC2 was highly expressed in the brain of mice chronically treated with antipsychotic drugs, resulting in lower expression of the receptor called mGlu2, and a recurrence of psychotic symptoms.
Randomized controlled trial of effect on quality of life of second-vs first- generation antipsychotic drugs in schizophrenia: Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUTLASS 1).
The antipsychotic drugs in question include conventional or first-generation medications such as chlorpromazine (Thorazine), along with atypical or second-generation antipsychotic medications, such as olanzapine (Zyprexa), which have been associated with an increased risk of cardiovascular death (Schizophrenia Research, Oct.
The metabolic syndrome during atypical antipsychotic drug treatment: mechanisms and management.
The study was designed to experimentally test the independent effects of antipsychotic drugs and of a psychosocial intervention they called "sociotherapy," as well as the interaction between the two.
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
The data showed that 12 percent of patients were discharged with a prescription for multiple antipsychotic drugs.