antiprothrombin

antiprothrombin

 [an″te-, an″ti-pro-throm´bin]
1. directed against prothrombin.
2. a substance that retards the conversion of prothrombin into thrombin.

an·ti·pro·throm·bin

(an'tē-prō-throm'bin),
An anticoagulant that inhibits or prevents the conversion of prothrombin into thrombin; examples are heparin (which is present in various tissues, especially in liver), and dicoumarin (which is isolated from partially decomposed sweet clover).

an·ti·pro·throm·bin

(an'tē-prō-throm'bin)
An anticoagulant that inhibits or prevents the conversion of prothrombin into thrombin (e.g., heparin, which is present in various tissues, especially in liver, and dicoumarin, which is isolated from partially decomposed sweet clover).
References in periodicals archive ?
The aPLs profile consisted of anticardiolipin (aCL) IgG, IgM, and IgA; anti-beta2-glycoprotein I IgG, IgM, and IgA (EUROIMMUN); antioxidized low-density lipoprotein IgG and IgM (IMTEC Immunodiagnostika, Berlin, Germany); antiprothrombin IgG, IgM, and IgA (AESKU.DIAGNOSTICS, Wendelsheim, Germany); antiphosphatidylserine (aPS) IgG and IgM (Demeditec Diagnostics, Kiel, Germany); antiphosphatidylethanolamine (aPE) IgG and IgM (The Binding Site, Birmingham, UK); and lupus anticoagulant (LA) performed with coagulation methods according to the International Society of Thrombosis and Haemostasis criteria [25].
All estimates are adjusted for age, renal disease, liver disease, initial blood pH, initial antiprothrombin time, and initial activated partial thromboplastin time.
Antiannexin V and antiprothrombin were performed as previously described [11, 15] and confirmed by dot blot.
Lupus anticoagulants cause a prolongation of the aPTT, probably as a result of hypoprothrombinemia induced by antiprothrombin antibodies.
Anticardiolipin, anti-[[beta].sub.2]-glycoprotein I and antiprothrombin antibodies in black South African patients with infectious disease.
Differential effects of anti-beta2glycoprotein I and antiprothrombin antibodies on the anticoagulant activity of activated protein C.
Antiprothrombin (aPT) antibodies, which are present in ~50% of antiphospholipid-positive patients (14) and are frequently found in women with APS, show wide variation in immunological and functional properties, depending mainly on their affinity for human prothrombin (or factor II), a vitamin K-dependent glycoprotein that performs several anticoagulant activities (15).