antiplatelet antibodies

antiplatelet antibodies

Antibodies that attack blood PLATELETS. Most are formed as a result of an AUTOIMMUNE process but some cases result from passage of maternal antibodies through the placenta before birth, or from platelet transfusion. Autoantibodies are common in SYSTEMIC LUPUS ERYTHEMATOSUS or HUGHES' SYNDROME. The effect of antiplatelet antibodies is to produce a drop in the number of platelets (THROMBOCYTOPENIA).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Evidence for an immune mechanism may include rapid response to corticosteroids, positive Coombs tests, or the presence of antiplatelet antibodies. Antiplatelet antibodies can be difficult to detect by the usual tests and have a little correlation between their titer and the degree of thrombocytopenia.
[1] EDTA dependent pseudothrombocytopenia is a rare phenomenon (i.e., around 0.1% in general population) which is mostly due to the presence of EDTA-dependent antiplatelet antibodies that react optimally between 0 [degrees]C to 4 [degrees]C, recognise the cytoadhesive receptors gpUb/IIIa, stimulate the expression of activation antigen, trigger activation of trypsin kinase, platelet agglutination and clumping in vitro.
The most common viral agents that cause infectious diseases in childhood can potentially cause a transient immunological deregulation that leads to the production of antiplatelet antibodies and ITP with acute and self-limiting characteristics.
Demonstration of serum antiplatelet antibodies in experimental acute canine ehrlichiosis.
Antiplatelet antibodies detected by the MAIPA assay in newly diagnosed immune thrombocytopenia are associated with chronic outcome and higher risk of bleeding.
(5) However, he was not in reaction and there were no antiplatelet antibodies or evidence of an immune etiology for the thrombocytopenia.
Prevalence of antiphospholipid and antiplatelet antibodies in human immunodeficiency virus (HIV)-infected Chilean patients.
Antithyroid antibodies and antiplatelet antibodies were negative.
In virus-associated ITPs, antiplatelet antibodies or virus antibody-immune complex has been associated with platelet destruction (75).