antiplatelet antibodies

antiplatelet antibodies

Antibodies that attack blood PLATELETS. Most are formed as a result of an AUTOIMMUNE process but some cases result from passage of maternal antibodies through the placenta before birth, or from platelet transfusion. Autoantibodies are common in SYSTEMIC LUPUS ERYTHEMATOSUS or HUGHES' SYNDROME. The effect of antiplatelet antibodies is to produce a drop in the number of platelets (THROMBOCYTOPENIA).
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1% in general population) which is mostly due to the presence of EDTA-dependent antiplatelet antibodies that react optimally between 0 [degrees]C to 4 [degrees]C, recognise the cytoadhesive receptors gpUb/IIIa, stimulate the expression of activation antigen, trigger activation of trypsin kinase, platelet agglutination and clumping in vitro.
Tenders are invited for IHiT / P / 79/2015 - Delivery of reagents and consumables for automatic isolation of DNA from fresh or frozen blood with the lease of the camera, reagents and consumables for the determination of IgG antiplatelet antibodies targeting antigens HPA-1,2,3,4 5, GPIV and HLA class.
Demonstration of serum antiplatelet antibodies in experimental acute canine ehrlichiosis.
Antiplatelet antibodies detected by the MAIPA assay in newly diagnosed immune thrombocytopenia are associated with chronic outcome and higher risk of bleeding.
5) However, he was not in reaction and there were no antiplatelet antibodies or evidence of an immune etiology for the thrombocytopenia.
Prevalence of antiphospholipid and antiplatelet antibodies in human immunodeficiency virus (HIV)-infected Chilean patients.
Antithyroid antibodies and antiplatelet antibodies were negative.
Antiplatelet antibodies contribute to thrombocytopenia associated with chronic hepatitis C virus infection.
Their application leads to stabilization of the capillaries, resulting in a reduction of bleeding, and their presence slows the synthesis of antiplatelet antibodies.
AS far as the antiplatelet antibodies are concerned It is true that a positive antigen-specific assay provides confirmatory evidence for the diagnosis in patients suspected of having immune thrombocytopenia while a negative test does not rule it out [4] platelet bound autoantibodies can be detected
5) ITP is an autoimmune condition caused by antiplatelet antibodies, which result in decreased platelet survival.
In both our patients, the appearance of antiplatelet antibodies was confirmed with direct and indirect platelet microimmunoflouroscence test for the heparin antibodies formation (ID-Card Heparin/ PF4 antibody test[R], DiaMed AG, France), and in both patients tests were repeated daily and were highly positive.