antiplasmin


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antiplasmin

 [an″te-, an″ti-plaz´min]
a substance in the blood that inhibits plasmin. The most important is α2-antiplasmin, which acts by forming stable complexes with free plasmin. It is also crosslinked to fibrin by coagulation factor XIII and inhibits the binding of plasminogen to fibrin. Inherited deficiency of α2-antiplasmin results in tendency to severe bleeding, including extravasation into joints or their synovial cavities.

an·ti·plas·min

(an'tē-plaz'min),
A substance that inhibits or prevents the effects of plasmin; found in plasma and some tissues, especially the spleen and liver.
Synonym(s): antifibrinolysin

an·ti·plas·min

(an'tē-plaz'min)
A substance that inhibits or prevents the effects of plasmin; found in plasma and some tissues, especially the spleen and liver.
Synonym(s): antifibrinolysin.
References in periodicals archive ?
In the presence of antiplasmins, such as alpha-2 macro globuli, in the plasma, the anti-fibrinolytic action of TXA is poetntiated.
Caption: Figure 1: Activated factor XIII (FXIIIa) partially prevents [alpha]2- antiplasmin ([alpha]2AP) from being expelled from a plasma clot during compaction and thereby strongly inhibits fibrinolysis.
The production of plasminogen, alpha-2 antiplasmin, histidine-rich glycoprotein and FXIII is decreased in liver diseases.
Plasmin (a fibrinolytic enzyme that breaks down blood clots) is rapidly blocked by a protein called antiplasmin. ECE compounds are natural potent inhibitors of antiplasmin, capable of efficient promotion of plasmin.
Measurements included complete blood count (CBC); platelets; PT; activated partial thromboplastin time (APTT); fibrinogen (clottable, immunological); coagulation factors II, V, VII, VIII, IX, X, XI, XII; anti-thrombin (AT); alpha-2 antiplasmin (AP); Protein C (PC); mixing studies; lupus anticoagulant screening; plasminogen; thrombin-anti-thrombin; fibrin degradation products (FDP); d-dimer; and thrombin time.
Inhibitory proteins, such as plasminogen activator inhibitor-1 (PAI-1) and antiplasmin, help regulate the rate of fibrinolysis (Diethorn & Weld, 1989; Comp, 1990).
The methods used were as follows: fibrinogen was measured by the Clauss method [4] protein S activity was measured using the IL Test[TM], an assay based on the prolongation of prothrombin time; protein C activity, tissue plasminogen activator (tPA), antithrombin III (AT III), plasminogen activator inhibitor (PAI) and antiplasmin were measured photometrically using chromogenic techniques (Chromogenix[TM] kits).
Collen, "On the kinetics of the reaction between human antiplasmin and a low-molecular-weight form of plasmin," European Journal of Biochemistry, vol.
Horvath, "Contribution of conserved lysine residues in the [alpha]2- antiplasmin C terminus to plasmin binding and inhibition," Journal of Biological Chemistry, vol.
Mesalazine therapy is recommended according to one paper [36] and antiplasmin tranexamic acid according to another [26].
Coagulation factors II, V, IX, X, XI, and XII, plasminogen, and alpha-2 antiplasmin and risk of coronary heart disease.
Uromodulin, SERPINF1 (serpin peptidase inhibitor, clade F, [alpha]-2 antiplasmin, pigment epithelium derived factor, member 1), and CD44 were verified in an independent cohort and shown to differentiate patients with AR from other groups.