Antiphospholipid syndrome (APS) was suspected due to the prolonged APTT at both 0 and 2 h following incubation with normal serum and the positive antiphospholipid antibodies
results (lupus anticoagulant 2.
Keywords: Immune thrombocytopenia, Helicobacter pylori, Hepatitis C virus, Brucella, Antiphospholipid antibodies
Moreover, their cumulative organ involvements and existence of cumulative antiphospholipid antibodies
(anticardiolipin immunoglobulins M and G, lupus anticoagulant) and antiphospholipid syndrome (according to 2006 Sapporo criteria) were recorded.
(APLA) are a group of autoantibodies, all recognising various combinations of phospholipids.
Anti-phospholipid syndrome is a disorder of the immune system, where abnormal antibodies, called antiphospholipid antibodies
(aPL) are produced.
Neurocognitive dysfunction in systemic lupus erythematosus: association with antiphospholipid antibodies
, disease activity and chronic damage.
40) Antiphospholipid antibodies
are known to cross-react with RBC membrane phospholipid epitopes and were found to produce positive DAT findings in 16% of patients with antiphospholipid syndrome and 4.
These tests included a hypercoagulability workup including prothrombin time, partial thromboplastin time, antiphospholipid antibodies
, protein C and S activity, antithrombin III activity, homocysteine level, and prothrombin F2 G20210A mutation.
Screening for antiphospholipid antibodies
at diagnosis is useful.
Lupus can cause other adverse pregnancy outcomes, including transient neonatal rash, neonatal thrombocytopenia, maternal preeclampsia, and recurrent fetal loss and thrombosis associated with antiphospholipid antibodies
Whether a woman with antiphospholipid antibodies
meets diagnostic criteria for antiphospholipid syndrome makes a huge difference in her risk of pregnancy failure.
In light of this, further research is warranted into a highly promising alternative hypothesis: that in utero exposure to SLE-related autoantibodies, such as anti-DNA and antiphospholipid antibodies
, may play a causative role, said Dr.