The most frequently prescribed drugs for chronic diseases include antidiabetics, antihypertensives, antipeptic
ulcer medications, and medications for heart disease, cancer, cerebral vascular disease, hyperlipidemia, and psychiatric disorders.
Apart from NSAIDs, other areas covered by ring bioisosterism include antibacterial folate antagonists, autonomic (Barreiro and coworkers work on tacrine for new selective acetylcholinesterase (AChE) inhibitors), antipeptic
ulcer drugs, antidepressant (work of Watthey and coworkers), sexual erectile dysfunction etc.
The dried flower heads of the plant Chamomile have been widely used in traditional and herbal medicine for centuries because of its anti-inflammatory, spasmolytic, antipeptic
, sedative, antibacterial and antifungal properties (Avallone et al., 2000; Zanoli et al., 2000; Fidler et al., 1996).
Obviously, it is important for patients with persistent or recurrent symptoms despite antipeptic
therapy to undergo endoscopic examination even if they are younger than 45.[16,29]