antioxidant therapy

antioxidant therapy

A general term for the use of any agent (e.g., antioxidant vitamins, glutathione reductase, superoxide dismutase) to reduce or eliminate oxygen free-radicals (OFRs) or excited oxygen molecules, which are by-products of normal metabolic reactions; excess OFRs have been linked to cancer secondary to OFR-induced DNA damage, and to cardiovascular disease secondary to FR-induced oxidation of low-density lipoprotein (LDL)-cholesterol to a more atherogenic form. In cardiology, antioxidant therapy attempts to block the oxidative modification of LDL, which is thought to be an early step in fatty streak development, atherogenesis and atherosclerosis-related pathologies, including coronary artery disease and cerebrovascular accidents.

antioxidant therapy

Therapeutics A general term for the use of any agent–eg, antioxidant vitamins, glutathione reductase, superoxide dismutase, to 'scavenge' O2 free radicals–OFRs or excited O2 molecules, which are by-products of normal metabolic reactions; excess OFRs have been linked to cancer 2º to OFR-induced DNA damage, and to cardiovascular disease 2º to OFR-induced oxidation of LDL-cholesterol to a more atherogenic form; in cardiology, AT attempts to block the oxidative modification of LDL, which is thought to be an early step in fatty streak development, atherogenesis and ASHD-related pathologies–eg, CAD and CVAs. See Antioxidant, Antioxidant vitamin.
References in periodicals archive ?
The study paves the way for further research into the pathophysiology of oxidative stress and the role of antioxidant therapy leading to appropriately designed clinical trials in which the promise of antioxidant therapy will be realised.
Zini A, Al-Hathal N: Antioxidant therapy in male infertility: fact or fiction?
Antioxidant status in rheumatoid arthritis and role of antioxidant therapy.
Though these results do not favor antioxidant therapy, it might be due to prooxidative effects of these antioxidants under these conditions as well as terms and the scheme of their administration.
It might be helpful "to stop thinking of antioxidant therapy as a branch of nutrition and instead view it as a drug discovery and development program.
Therapeutic benefit with antioxidant therapy has been demonstrated in some diseases such as chronic idiopathic pancreatitis.
Currently, there are studies demonstrating a statistically significant reduction in the number of leukocytes in the seminal plasma, improving sperm cells motility in the course of antioxidant therapy [7].
Free radicals and oxidative stress are involved in many diseases and respond positively to antioxidant therapy.
The continuous stimulation of LPS may be too overwhelming for the macrophages thus inhibiting the benefits of antioxidant therapy.
Antioxidant therapy in children affected by irradiation from the Chernobyl nuclear accident.
The causal association of oxidative stress and hypertension had also been supported by the observation that antioxidant therapy ameliorates hypertension in experimental models (Atarashi et al.