antioxidant therapy

antioxidant therapy

A general term for the use of any agent (e.g., antioxidant vitamins, glutathione reductase, superoxide dismutase) to reduce or eliminate oxygen free-radicals (OFRs) or excited oxygen molecules, which are by-products of normal metabolic reactions; excess OFRs have been linked to cancer secondary to OFR-induced DNA damage, and to cardiovascular disease secondary to FR-induced oxidation of low-density lipoprotein (LDL)-cholesterol to a more atherogenic form. In cardiology, antioxidant therapy attempts to block the oxidative modification of LDL, which is thought to be an early step in fatty streak development, atherogenesis and atherosclerosis-related pathologies, including coronary artery disease and cerebrovascular accidents.

antioxidant therapy

Therapeutics A general term for the use of any agent–eg, antioxidant vitamins, glutathione reductase, superoxide dismutase, to 'scavenge' O2 free radicals–OFRs or excited O2 molecules, which are by-products of normal metabolic reactions; excess OFRs have been linked to cancer 2º to OFR-induced DNA damage, and to cardiovascular disease 2º to OFR-induced oxidation of LDL-cholesterol to a more atherogenic form; in cardiology, AT attempts to block the oxidative modification of LDL, which is thought to be an early step in fatty streak development, atherogenesis and ASHD-related pathologies–eg, CAD and CVAs. See Antioxidant, Antioxidant vitamin.
References in periodicals archive ?
At present, my treatment of AD patients consists of (1) removal of all sedatives, which often increase confusion; (2) control of agitation by use of propranolol titrated to need; (3) antioxidant therapy (our antiOx formula); (4) drugs that promote neurogenesis--frequently antidepressants fill this function; (5) a safe-for-long-term antiinflammatory agent such as montelukast; (37) and if needed an anticholinesterase inhibitor.
At present, the Vitamin E is used as promising antioxidant therapy in moderately severe AD.
Preventing barium uptake by supporting the calcium metabolism might be a more suitable treatment method, and antioxidant therapy might also be a suitable option but again, more studies are needed to support these claims.
A review of antioxidant therapy and discovery of male infertility biomarkers is provided in this paper.
A recently published meta-analysis revealed possible benefit of antioxidant therapy for AP, and this may also be an evidence that the depletion of antioxidants take place in the pathogenesis of AP (26).
However, the addition of antioxidant therapy to other types of NAFLD treatment may not always be associated with a greater beneficial effect.
The study paves the way for further research into the pathophysiology of oxidative stress and the role of antioxidant therapy leading to appropriately designed clinical trials in which the promise of antioxidant therapy will be realised.
Webb believes that oxidative stress--an imbalance in free radicals that can damage cells--plays a role, and that there may be a place for antioxidant therapy but says, "It is also likely that type 2 diabetic cats are different from type 2 humans and we just need to be smarter when it comes to figuring out this very complex process in this even more mysterious species!"
The determination of total antioxidant capacity is a more reliable and comprehensive way to evaluate oxidative stress and monitor antioxidant therapy. Measurement of total antioxidant capacity better reflects the body's redox state [15] than determination methods that measure only a single antioxidant substance or a small number of antioxidants.