antiestrogen(redirected from antioestrogen)
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a generic term for any of the estrus-producing compounds (female sex hormones), including estradiol, estriol, and estrone. Called also estrogenic hormone. In humans, the estrogens are formed in the ovary, adrenal cortex, testis, and fetoplacental unit, and are responsible for female secondary sex characteristic development, and during the menstrual cycle, act on the female genitalia to produce an environment suitable for fertilization, implantation, and nutrition of the early embryo. Uses for estrogens include oral contraceptives, hormone replacement therapy, advanced prostate or postmenopausal breast carcinoma treatment, and osteoporosis prophylaxis.
conjugated e's a mixture of the sodium salts of the sulfate esters of estrone and equilin; therapeutic uses are similar to those of other estrogens; administered orally, intravenously, intramuscularly, or intravaginally.
Any substance capable of preventing full expression of the biologic effects of estrogenic hormones on responsive tissues, either by producing antagonistic effects on the target tissue, as androgens and progestogens do, or by competing with estrogens at estrogen receptors at the cellular level (for example, tamoxifen).
Synonym(s): estrogen antagonist
Any substance capable of preventing full expression of the biologic effects of estrogenic hormones on responsive tissues.