antinucleoside analogue

antinucleoside analogue

Therapeutics Any of a family of compounds that resemble natural nucleotide bases-the building blocks of DNA, which are used as antivirals; ANAs selectively interfere with viral DNA replication, without interfering with cellular DNA replication Adverse effects Short-term, minimal; long-term, adverse systemic effects on oxidative phosphorylation, which has features of inherited mitochondrial diseases, resulting in myopathy, cardiomyopathy, neuropathy, lactic acidosis, failure of exocrine pancreas, liver, BM
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