antinuclear antibody


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an·ti·nu·cle·ar an·ti·bod·y (ANA),

an antibody showing an affinity for nuclear antigens including DNA and found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and certain collagen diseases, and in some of their healthy relatives; as well as about 1% of otherwise healthy people. Different antinuclear antibodies generate distinctive patterns on immunofluorescence staining tests. These patterns have clinical relevance and reflect which nuclear constituents (autoantigens) are generative specific antibody responses.

antinuclear antibody

n. Abbr. ANA
Any of various antibodies that react with nuclear antigens such as nucleic acids and histones and are often present in the blood of people with systemic autoimmune rheumatic diseases.

antinuclear antibody (ANA)

[-no̅o̅′klē·ər]
an autoantibody directed against nuclear antigens. Antinuclear antibodies are found in the blood serum of patients with rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, polymyositis, scleroderma, Raynaud's disease, mixed connective tissue disease, and a number of nonrheumatic disorders ranging from lymphomas, leukemias, primary biliary cirrhosis, thyroiditis, chronic active hepatitis, and adverse drug reactions. The antibodies are often detected with an immunofluorescent assay technique.

antinuclear antibody

Any of a number of circulating antibodies directed against various antigens in the nucleus, including histone, double- and single-stranded DNA, and ribonucleoprotein. ANAs are often present in serum of patients with SLE and other connective tissue diseases.

antinuclear antibody

ANA Immunology Any of a number of circulating antibodies that are directed against various antigens in the nucleus, including histone, double- and single-stranded DNA, and ribonucleoprotein; ANAs are often present in serum of Pts with SLE and other connective tissue diseases. See Speckled pattern.

an·ti·nu·cle·ar an·ti·bod·y

, antinuclear factor (ANA, ANF) (an'tē-nū'klē-ăr an'ti-bod-ē, fak'tŏr)
An antibody showing an affinity for cell nuclei, demonstrated by exposing a cell substrate to the serum to be tested, followed by exposure to an antihuman-globulin serum; found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and certain collagen diseases, in some of their healthy relatives, and in about 1% of unaffected people.

antinuclear antibody,

n an autoantibody that reacts with nuclear material and is present in indivi-duals with autoimmune disorders; detectable by immunoflourescent assay technique.

an·ti·nu·cle·ar an·ti·bod·y

, antinuclear factor(ANA, ANF) (an'tē-nū'klē-ăr an'ti-bod-ē, fak'tŏr)
An antibody showing an affinity for cell nuclei, demonstrated by exposing a cell substrate to the serum to be tested, followed by exposure to an antihuman-globulin serum; found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and some collagen diseases.

antinuclear antibody

see antinuclear antibody.
References in periodicals archive ?
8 45 F Isoniazide, Diclofenac Erythema multiforme sodium, Ibuprofen, with oral erosions Ketorolac, Etoricoxib 9 36 F Acetaminophen, Mefenamic Urticaria acid, Tranexamic acid, Ketorolac, Ranitidine 10 67 F Acetaminophen, Ranitidine DRESS Diclofenac sodium, Exfoliative Alendronate dermatitis Serial Co-morbidity Antinuclear Antibody No Profile 1 None Negative 2 None Anti-PCNA antibody positive 3 None Negative 4 None Negative 5 Chronic hip and knee Anti-dsDNA, joint pain, Lupus antinucleosome, nephritis antihistone,, anti-U1RNP and anti-Ku antibodies positive 6 ?
Arthralgias, lymphopenia, raised globulins and markedly raised ESR brought our mind towards some autoimmune process, but antinuclear antibody (ANA) and direct Coombs test were negative.
However, Antinuclear antibody, anti-nRNP antibody and anti-histone antibody were still positive.
Immunological study revealed the presence of anti-SS (Soluble Substance)-A-165RU/ml, anti-SS (Soluble Substance)B autoantibodies 175RU/ml and Anti-Ro52 and Antinuclear Antibody (HeP2-Fine Speckled & Homogenous) positive.
The negative result in the antinuclear antibody testing argued against Sjogren syndrome, however.
9 mg/dL, serum angiotensin converting enzyme level of 27 U/L (normal 9-67 U/L), negative antinuclear antibody, negative anticardiolipin antibodies (IgG, IgA, IgM), normal levels of serum [beta]2 glucoprotein antibody, negative human immunodeficiency virus antibody, microalbuminuria, and normal hepatic aminotransferases.
Rheumatoid factor is positive in 70% of patients with rheumatoid arthritis, and the antinuclear antibody is invariably positive for patients with SLE.
Expression and clinical significance of antinuclear antibody in hepatitis C virus infection.
Measurements of the complete blood count, erythrocyte sedimentation rate, antineutrophil cytoplasmic antibody (ANCA) level, and antinuclear antibody (ANA) level were all within normal ranges.
Other commercially-available EliA assays include Cyclic Citrullinated Peptide (CCP), tissue Transglutaminase (tTG) IgA and IgG (Celikey([R])), Gliadin IgA and IgG, dsDNA, Extractable Antinuclear Antibody (Symphony), and ENA antibodies to the following antigens: Sm, U1RNP, RNP70, Ro, La, Scl-70, CENP and Jo-1.
Arguably one of the most commonly ordered autoantibody tests, the antinuclear antibody (ANA) test is frequently used in a variety of medical disciplines including rheumatology.
Evaluation of immunoblotting test results in patients with positive antinuclear antibody.