antinuclear antibody


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an·ti·nu·cle·ar an·ti·bod·y (ANA),

an antibody showing an affinity for nuclear antigens including DNA and found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and certain collagen diseases, and in some of their healthy relatives; as well as about 1% of otherwise healthy people. Different antinuclear antibodies generate distinctive patterns on immunofluorescence staining tests. These patterns have clinical relevance and reflect which nuclear constituents (autoantigens) are generative specific antibody responses.

antinuclear antibody

n. Abbr. ANA
Any of various antibodies that react with nuclear antigens such as nucleic acids and histones and are often present in the blood of people with systemic autoimmune rheumatic diseases.

antinuclear antibody

Any of a number of circulating antibodies directed against various antigens in the nucleus, including histone, double- and single-stranded DNA, and ribonucleoprotein. ANAs are often present in serum of patients with SLE and other connective tissue diseases.

antinuclear antibody

ANA Immunology Any of a number of circulating antibodies that are directed against various antigens in the nucleus, including histone, double- and single-stranded DNA, and ribonucleoprotein; ANAs are often present in serum of Pts with SLE and other connective tissue diseases. See Speckled pattern.

an·ti·nu·cle·ar an·ti·bod·y

, antinuclear factor (ANA, ANF) (an'tē-nū'klē-ăr an'ti-bod-ē, fak'tŏr)
An antibody showing an affinity for cell nuclei, demonstrated by exposing a cell substrate to the serum to be tested, followed by exposure to an antihuman-globulin serum; found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and certain collagen diseases, in some of their healthy relatives, and in about 1% of unaffected people.

an·ti·nu·cle·ar an·ti·bod·y

, antinuclear factor(ANA, ANF) (an'tē-nū'klē-ăr an'ti-bod-ē, fak'tŏr)
An antibody showing an affinity for cell nuclei, demonstrated by exposing a cell substrate to the serum to be tested, followed by exposure to an antihuman-globulin serum; found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and some collagen diseases.
References in periodicals archive ?
Ledue, "The relationship between antinuclear antibody data and antibodies against extractable nuclear antigens in a large laboratory cohort," Clinical Chemistry and Laboratory Medicine, vol.
Antinuclear antibody profile detected positivity (Table 1) in four others (All females).
Clinical features and evolution of antinuclear antibody positive individuals in a rheumatology outpatient clinic.
Antinuclear antibody test,Anti-Smith,Autoantibodies,Autoimmune disease,Discoid lupus erythematosus,Drug-induced systemic lupus erythematosus,Lupus,Systemic lupus erythematosus
(a) Adjusted for age, smoking status, total years of pesticide exposure (quartiles), cholesterol, and triglycerides; one value was missing for IgA, for a total number of 136 for IgA analyses and 137 for IgG and antinuclear antibody analyses.
According to report published by Grand View Research, The global antinuclear antibody test market size was valued at USD 923.1 million in 2017.
The serology tests segment is further divided into six sub-segments are-erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP), antinuclear antibody (ANA), uric acid and other tests.
Further work up showed that he had elevated ferritin 6542ng/mL, high triglycerides 327mg/dL, marked decreased complement levels (C3 14mg/dL and C4 3 mg/dL), elevated ESR 137mm/hr, strongly positive for antinuclear antibody (ANA, 1: 640), and anti-doublestranded DNA antibody (anti-dsDNA, >1:1280).
SLE was diagnosed according to the 1992 criteria of the American College of Rheumatology, based on clinical manifestations and the results of blood and urine analysis, including tests for antinuclear antibody, anti-double-stranded deoxyribonucleic acid antibody, anti-Sjogren's syndrome type A (anti-Ro/SSA) antibody, anti-Sjogren's syndrome type B (anti-La/SSB) antibody, anti-cardiolipin (aCL) antibody, and complement 3 (C3) and complement 4 (C4).
Investigation At presentation 6 weeks after treatment Hemoglobin (gm/dL) 10.3 13.4 Mean corpuscular volume (MCV) (fL) 112 94.6 Serum vitamin B12 (pg/mL) 83 >2000 Serum folic acid (ng/mL) >20 13.75 Methylmalonic acid (MMA) (nmol/l) 54.800 -- Anti-intrinsic factor antibodies Positive Antinuclear antibody (ANA) Negative Investigation Reference range Hemoglobin (gm/dL) 12.5-17.5 gm/dL Mean corpuscular volume (MCV) (fL) 78-100 fL Serum vitamin B12 (pg/mL) 200-1200 pg/mL Serum folic acid (ng/mL) 4.6-18.7 ng/mL Methylmalonic acid (MMA) (nmol/l) 87-318 nmol/l Anti-intrinsic factor antibodies Antinuclear antibody (ANA)
A consult with a rheumatologist can be helpful, as in this case, if a patient has a positive antinuclear antibody test, which could not be explained, she added, noting that the patient is doing well after 6 months of therapy.
Rowell syndrome is usually diagnosed by the presence of erythema multiforme (EM)-like targetoid lesions in the patients of cutaneous or systemic lupus erythematosus (CLE/SLE) and characterized by specific serological or immunological profile like speckled antinuclear antibody (ANA) pattern, antibody against saline extract of human tissues (anti-SjT) and positive serum rheumatoid factor (RF).