antineutrophil cytoplasmic antibody


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Related to antineutrophil cytoplasmic antibody: Wegener's granulomatosis, vasculitis, antinuclear antibody, Protein electrophoresis

antineutrophil cytoplasmic antibody

an autoantibody to cytoplasmic constituents of monocytes and neutrophils found in patients with vasculitis.

antineutrophil cytoplasmic antibody

ANCA Immunology Any autoantibody directed against certain components of granulocytes, myeloid-specific lysosomal enzymes; ANCAs are most commonly found in systemic vasculitides–eg, necrotizing vasculitis, active generalized Wegener's granulomatosis–WG, 84-100% are positive, polyarteritis nodosa, inflammatory conditions of the lung and kidney–eg, crescentic glomerulonephritis, unexplained renal failure, Churg-Strauss syndrome, HIV infection, IBD, drug-induced lupus, SLE, rheumatoid arthritis, and others

an·ti·neu·tro·phil cy·to·plas·mic an·ti·bod·y

(ANCA) (an'tē-nū'trō-fil sī'tō-plaz'mik an'ti-bod-ē)
An autoantibody to cytoplasmic constituents of monocytes and neutrophils found in patients with vasculitis.

antineutrophil cytoplasmic antibody

Abbreviation: ANCA
An autoantibody found in the blood of patients with certain forms of vasculitis (such as Churg-Strauss syndrome, microscopic polyangiitis, Wegener granulomatosis) esp. when it affects small blood vessels.
See also: antibody
References in periodicals archive ?
Liang et al., "Treatment and clinicopathological characteristics of lupus nephritis with antineutrophil cytoplasmic antibody positivity: a case-control study," BMJ Open, vol.
A literature search of previously published cases concerning ANCA induction in infective endocarditis was performed via PubMed and Medline using the title and abstract entries "endocarditis" and "ANCA or antineutrophil cytoplasmic antibody," yielding 70 relevant cases [1,5-39].
Anti-thyroid drugs and antineutrophil cytoplasmic antibody positive vasculitis.
One of the critical elements of the diagnostic evaluation is laboratory testing for antineutrophil cytoplasmic antibody (ANCA) and proteinase 3 (PR3).
The antineutrophil cytoplasmic antibody (ANCA) tests are the first serologies to order when a patient is suspected of having some kind of vasculitis as manifest, for example, by diffuse alveolar hemorrhage, nephritis without another explanation, or a pulmonary-renal syndrome.
Crohn's disease and sarcoidosis, deep fungal infection (candida, histoplasmosis and paracoccidioidomycosis), tuberculosis ,other granulomatous infections like midline lethal granuloma, midline NK/T-cell lymphomas, other antineutrophil cytoplasmic antibody (ANCA) positive vasculitis, drug induced gingival enlargement and rarely cicatricialpemphigoid (CP) or mucous membrane pemphigoid should be included in the differential diagnosis of Wegener's granulomatosis.
Order a urine culture, serum BUN and creatinine measures, a renal ultrasound, and "some serology" such as antinuclear antibody, C3, Streptozyme, or antineutrophil cytoplasmic antibody tests, he said.
Clinical applications of antineutrophil cytoplasmic antibody testing.
Antineutrophil cytoplasmic antibody correlates with chronic pouchitis after ileal pouch-anal anastomosis.
Antineutrophil cytoplasmic antibody in inflammatory bowel and hepatobiliary diseases.
The antineutrophil cytoplasmic antibody (ANCA) testing revealed low-positive anti-myeloperoxidase (MPO) by enzyme-linked immunosorbent assay (ELISA) (1.5 units; reference range, 0–1.0 units).
(26,27) Antineutrophil cytoplasmic antibody continues to be a valuable tool for evaluation of vasculitides, and newer studies suggest ANCA can be a useful diagnostic test in other diseases as well.