. Darifenacin (Enablex), fesoterodine (Toviaz), flavoxate (Urispas), oxybutynin (Ditropan), solifenacin (Vesicare), tolterodine (Detrai), and trospium (Sanctura).
While analyzing the prescriptions, the academics found that most frequently prescribed anticholinergic drugs were bladder antimuscarinic
drugs, antidepressants, drugs for treating vomiting, motion sickness and drugs to treat vertigo.
Mirabegron is an oral [beta]3-adrenoreceptor agonist which has emerged as an alternative to antimuscarinics
for the medical treatment of OAB.
It has been reported that the topical administration of high concentrations of antimuscarinics
to the brain produced seizures (33, 34).
Scrine, "Persistence and adherence with mirabegron vs antimuscarinics
in overactive bladder: retrospective analysis of a UK general practice prescription database," International Journal of Clinical Practice, vol.
Secondly, when urgency is diagnosed, the use of antimuscarinics
should be considered.
In the EAU guideline, it is stated that onaBoNT-A is a successful minimally invasive treatment method for NDO in patients with MS or SCI, where antimuscarinic
treatment was ineffective.
* Anticholinergic drugs with antimuscarinic
effects, such as oxybutynin, may be used to treat symptoms of urge incontinence and overactive bladder.
patients already treated with antimuscarinics
, especially those with
for treatment of overactive bladder.
Pharmacologic agents often implicated as the cause of acute urinary retention include tricyclic antidepressants, opioid analgesics, antipsychotics, antimuscarinics
, and aadrenergic agonists .
Background: The medium-to-long-term use of antimuscarinics
alone or in combination with an a-blocker in men with an enlarged prostate is still controversial.