antimicrosomal antibodies

antimicrosomal antibodies

Antithyroid microsomal antibodies Endocrinology Antibodies directed against components of thyroid microsomes, in particular peroxidase; AMAs are the most useful of antithyroid antibodies as they are often present in thyroid disease, and in higher titers than those for antithyroglobulin antibodies, especially in younger Pts; AMAs are present in Hashimoto's thyroiditis-99% positive, Graves' disease-80%, hypothyroidism, atrophic thyroiditis, and are ↑ in the elderly. See Antithyroglobulin antibodies, Antithyroid antibodies.
References in periodicals archive ?
Antimicrosomal antibodies and antithyroglobulin antibodies were determined by enzyme linked immunoassay (ELISA) according to the methods of [20] and [21] respectively.
There was a significant increase in antimicrosomal antibodies in SHypo patients (66 % SHypo vs.
Antimicrosomal and antithyroglobulin antibodies (llU/ml) percent G1 G2 Antimicrosomal antibodies 0.00% 66% Antithyroglobulin antibodies 0.00% 66% Note: Table made from bar graph.
Antithyroid antibodies: 1) Antinuclear antibodies (ANA) were analyzed by immune-fluorescence and 2) Antimicrosomal antibodies (AMA) by passive haemaglutination.
The presence of antimicrosomal antibodies (AMA) was found in two of five euthyroid patients (patients 3 and 5).
One year earlier, the same authors reported a somewhat higher incidence of thyroid disease in a larger series (n=104) of MG patients (6% with thyrotoxicosis, 2% with hypothyroidism, 12% had antithyroglobulin antibodies and 28% had antimicrosomal antibodies) (6).
TABLE Autoimmune markers in thyroid disorders % TRAb % TRAb % OF >3.4 U/L >10 U/L STUDY PATIENTS LR+ LR- LR+ LR- Graves' disease 68 4.6 0.1 13.0 0.2 CAHT 20 0.2 4.7 0.1 2.8 Subacute 4 0.2 3.0 0.0 2.4 thyroiditis Thyroid nodules 6 0.2 3.4 0.0 2.4 Others 2 0.8 1.4 0.0 2.3 % AMA % THYROGLOBULIN POSITIVE POSITIVE LR+ LR- LR+ LR- Graves' disease 1.3 0.6 1.1 0.9 CAHT 1.4 0.2 1.4 0.6 Subacute 0.1 3.6 0.5 1.5 thyroiditis Thyroid nodules 0.1 4.1 0.1 2.0 Others 0.0 2.8 0 2.0 AMA, antimicrosomal antibodies; CAHT, chronic autoimmune (Hashimoto's) thyroiditis; LR+, positive likelihood ratio; LR-, negative likelihood ratio; TRAb, thyrotropin receptor antibodies Source: Khoo DHC, et al.
Postoperatively, the patient's serum was tested for a number of autoimmune antibodies, including antinuclear antibodies, antineutrophil cytoplasmic antibodies, anti-SSA and anti-SSB antibodies, antimitochondrial antibodies, anti-smooth muscle antibodies, antimicrosomal antibodies, and antithyroglobulin antibodies, all of which were negative.
Table 1: Thyroid profile Before Admission (13/08/2014) Parameter Value (Normal Range) TSH >150 uIU/ml (0.3-5.5) T3 61 pg/ml (60-200) T4 3.4ng/ml (4.5-12) On admission (16/5/2015) Parameter Value (Normal range) TSH 21.9 uIU/ml (0-8-2) TSH-FT3 2.98 pg/ml (1.8-4.2) FT4 1.07ng/ml (0-8-2) Antimicrosomal antibodies (AMA/anti TPO) >600 IU/ml (<34) Antithyroglobulin antibodies (ATG) 383.1 IU/ml (<115) TSH Receptor antibody Ig 24.97 IU/L(n<1.75)
Odds ratio analyses revealed that postpartum women with positive antimicrosomal antibodies had a 6.5-to- 1 (95% Cl = 1.4 to 31.1, P = .01) risk for early disease when titers at delivery were [is greater than or equal to] 400.
Serum thyroid peroxidase antibodies, antimicrosomal antibodies are elevated in autoimmune thyroiditis.