The growing body of literature supports a move towards individualised and tailored antimicrobial therapy
.  This requires knowledge of the Pk-Pd parameters associated with clinical efficacy of an antimicrobial, which in turn creates a need for an MIC correlate given its direct relationship to these parameters.
Notably, among the patients with Pseudomonas bacteremia, 44% (24 out of 54) received inappropriate antimicrobial therapy
in the ED.
Conversely, active antimicrobial therapy
(odds ratio, 0.38; 95% confidence interval, 0.16-0.95; p = 0.04) and microorganism identification via MALDI-TOF MS (odds ratio, 0.28; 95% confidence interval, 0.12-0.66; p = 0.004) were protective factors.
PCT does not inform the specific etiology of infection, and thus microbiologic data are still needed for optimization of antimicrobial therapy
. A physiological increase in PCT can be observed in settings other than infection; for example, increases may be observed in postoperative patients as a result of inflammation from surgery.
Identification of optimal combinations for empirical dual antimicrobial therapy
of Pseudomonas ae-ruginosa infection: potential role of a combination antibiogram.
The appropriate duration of empirical antimicrobial therapy
for culture-negative suspected EOS is debated, but standard practice is to stop antimicrobials if the culture remains negative for 48-72 hours and the patient has no clinical or haematological signs of infection.
This report describes the first known use of a VAP for the long-term administration of intravenous antimicrobial therapy
in a bird.
chelonae native tricuspid valve endocarditis associated with a pacemaker lead was successfully treated with wire removal, valve debridement, and antimicrobial therapy
The difficulties of antimicrobial prescribing lie in selecting the right antimicrobial therapy
for the suspected pathogen and adjusting the dose and dosing frequency with an appropriate route of administration to ensure effective levels of medication are administered at the site of the infection.
in Veterinary Medicine, fifth edition
Due to the increase prevalence of multi-drug resistant microorganisms, synergism testing using various combinations of phytochemicals with antimicrobial agents could be a powerful tool in helping to select an antimicrobial therapy
more effective and less toxic (Hemaiswarya et al.
Thirty-nine chapters are divided into four sections: general principles of antimicrobial therapy
; classes of antimicrobial agents; special considerations; and antimicrobial drug use in selected animal species.