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Drugs have been analyzed by segments such as angiogenesis inhibitor, EGFR inhibitor, kinase inhibitor, microtubule stabilizer, folate antimetabolites, and PD-1/PD-L1 inhibitor.
Modufolin (chemical name [6R]-5,10- methylenetetrahydrofolate), is a novel folate-based compound developed to increase the efficacy and reduce the side effects of antimetabolites used in cancer treatment.
These studies indicate that TGF-[beta]2 may naturally modify the antiscarring effects of antimetabolites in glaucoma filtration surgery (Cordeiro et al.
The use of these drugs during pregnancy has been a concern, because they are cytotoxic antimetabolites that are also used as anticancer drugs, albeit at higher doses than those used for IBD.
In our patient, we were concerned that haemolysis due to DDS in the presence of bone marrow depression caused by the antimetabolites (the levels of which were unavailable at the time), could be catastrophic.
One of a group of chemotherapy drugs known as antimetabolites, it prevents cells from making DNA and RNA - ribonucleic acid - which causes cells to die.
Other topics of the 66 chapters include topoisomerase inhibitors, antimetabolites, cytokines, monoclonal antibodies, biophosphonates, anemia, metabolic emergencies, and pain management.
Antimetabolites are substances that are chemically very similar to the building blocks of DNA and RNA--purine and pyrimidine.
Antimetabolites are a broad class of drugs that interferes with the basic metabolism of cancer cells.
5) Current therapy involves the use of combinations of steroids (topical, oral, and IV), antimetabolites, and cytotoxic medications.
The growth spurt will be fueled by the development of new drugs with fewer side effects and prophylactic uses of acute immunosuppressive therapies such as novel antimetabolites, monoclonal, and polyclonal antibodies, which will increase the success of transplants, the company reports.
He starts with Paul Ehrlich's antitreponemal arsenicals and ends with the antisense agents now in early clinical trials for the treatment of autoimmune diseases and cancer, covering in the process the development of antibacterial and antiviral agents, vaccines, antimetabolites, and hormone-based antineoplastic agents.