The toxic effects of antimalarial drugs
are depicted by the total and relative weight of an organ after drug administration (Maina et al., 2008).
Timeline distribution of Plasmodium falciparum pfpm2 copy number status during post-DHA/PPQ treatment followup for artemisinin combination therapy efficacy trials conducted by the West African Network for Antimalarial Drugs
, Mali, Burkina Faso, and Guinea, October 2011-February 2016.
Recently there are various difficulties regarding the developing of new antimalarial drugs
, like cost, toxicity and drug resistance; nonetheless it has been considered globally the importance of finding new ways to improve antimalarial treatments (Hsu, 2006).
This comprised all NHIS outpatients' prescriptions that contained at least one antimalarial drug
filled from January to December 2013.
Although, the WHO does not recommend it as a first line antimalarial drug
for uncomplicated malaria, quinine is still used in the treatment of severe malaria and in cases where the ACTs fail to give the required therapeutic outcome.
AQ  is a potent antimalarial drug
but side effects of hepatotoxicity and agranulocytosis have limited its use.
In this study we aimed to give an overview and an assessment of an emerging important issue regarding antimalarial drug
resistance which threatens global efforts to control and eradicate malaria.
While Lariam is not the main antimalarial drug
used by the armed forces, at least 17,368 personnel were prescribed it at least once between the start of April 2007 and the end of March 2015, according to official MoD figures.
These cells were sensitive to an antimalarial drug
called atovaquone; chemical maturation through exposure to small molecules also made the cells sensitive to another antimalarial drug
called primaquine, demonstrating the value of this approach for testing new antimalarial drugs
CAMBRIDGE, Mass., February 5, 2015--Researchers here have developed a way to use human liver cells derived from induced pluripotent stem cells to screen potential antimalarial drugs
and vaccines for their ability to treat the liver stage of malaria infection.
Few studies also demonstrated that different clinical presentations of vivax malaria infection are strongly associated with a potent activation of pro-inflammatory responses and cytokine imbalance (8-11).The sequestration of parasitized RBCs in the pulmonary microcirculation may initiate lung damage via direct endothelial activation and recruitment of host inflammatory responses, which can continue after treatment with antimalarial drugs
. The occurrence of ARDS/ ALI when a parasite is declining or has been cleared suggests a post-treatment inflammatory effect as a contributory cause.
This study focus to design a novel antimalarial drug
(analog) against mutated PfDHFR by considering the in silico approaches.