antileukotriene


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an·ti·leu·ko·tri·ene

(an'tē-lū'kō-trī'ēn),
A drug that prevents or alleviates bronchoconstriction in asthma by blocking the production or action of naturally occurring leukotrienes; may also be useful in psoriasis.

Leukotrienes are eicosanoids derived from arachidonic acid, which is present in cell membranes. The cysteinyl leukotrienes, which are elaborated by bronchopulmonary mast cells, eosinophils, and probably alveolar macrophages, have been shown to mediate bronchoconstriction induced by exercise, hyperventilation in cold air, aspirin, and inhaled allergens. They act by stimulating a specific receptor, known as cysteinyl leukotriene receptor type 1 (CysLT1). Antileukotrienes having clinical usefulness in asthma include zileuton, which inhibits 5-lipoxygenase, an enzyme critical in the biosynthesis of leukotrienes, and leukotriene receptor antagonists (cinalukast, montelukast, zarirlukast, and others). Antileukotrienes reverse bronchconstriction in asthma to a lesser degree than β2-adrenergic agonists, but their effects are additive to those of the latter agents. In chronic asthma, antileukotrienes improve peak flow and FEV1 and reduce the frequency and severity of acute asthmatic attacks, the need for β2-agonists, and the need for corticosteroid rescue. They are particularly effective in the prophylaxis of asthma induced by exercise and aspirin. In contrast, many people with allergic asthma show little or no response. Antileukotrienes are not indicated in the treatment of an acute asthmatic attack or in mild, intermittent asthma controlled adequately with occasional use of inhaled β2-agonists. They have not been recommended as a substitute for inhaled corticosteroids in prophylaxis of asthma. Antileukotrienes are administered orally or by inhalation. Both onset and waning of clinical effects are gradual. Side-effects are minimal, but drug interactions may occur because of interference with cytochrome P-450 enzymes. Rare transitory elevations of hepatic aminotransferase have been reported with some agents.

antileukotriene

Any of a class of agents that either interferes with leukotriene synthesis or antagonises leukotriene receptors, which are as effective as cromolyn or theophylline, and may reduce the amount of inhaled steroids needed to control inflammation.

Antileukotrienes 
LTD4 receptor antagonists (Zafirkulast-Accolate)
 
Pros
LTD4-induced bronchoconstriction, early and late responses, exercise challenge, cold-induced asthma, chronic asthma.
 
5-Lipoxygenase inhibitor (Zileutron-Zyflo)
 
Pros
Asthma induced by exercise, cold, aspirin, bronchial hyperresponsiveness.
 
FLAP inhibitors (5-lipoxygenase-activating protein inhibitor)

Pros
Early and late responses and cold-induced asthma.

antileukotriene

Any of a class of agents that either interfere with leukotriene synthesis or antagonize leukotriene receptors, which are as effective as cromolyn or theophylline, and may ↓ the amount of inhaled steroids needed to control inflammation See Asthma, Leukotrienes, Zafirlukast, Zileuton.
Antileukotrienes
LTD4 receptor antagonists
Zafirkulast-Accolate® Benefits LTD4-induced bronchoconstriction, early and late responses, exercise challenge, cold-induced asthma, chronic asthma
5-Lipoxygenase inhibitor
Zileutron-Zyflo®Benefits asthma induced by exercise, cold, aspirin, bronchial hyperresponsiveness
FLAP inhibitors
None are FDA-approved Benefits early and late responses and cold-induced asthma
.

an·ti·leu·ko·tri·ene

(an'tē-lū-ko-trī'ēn)
A drug that prevents or alleviates bronchoconstriction in asthma by blocking the production or action of naturally occurring leukotrienes; may also be useful in psoriasis.

an·ti·leu·ko·tri·ene

(an'tē-lū-ko-trī'ēn)
A drug that prevents or alleviates bronchoconstriction in asthma by blocking the production or action of naturally occurring leukotrienes; may also be useful in psoriasis.
References in periodicals archive ?
Overall, 26 of the 36 patients (72%) experienced improvement in their symptomatology after starting antileukotriene therapy.
CLINICAL APPLICATION OF ANTILEUKOTRIENE DRUGS IN ASTHMA MANAGEMENT
The antileukotriene class is expected to see a rapid decline as Singulair succumbs to generic entry.
Antileukotriene drugs: clinical application, effectiveness and safety.
NO] for the two subjects taking antileukotriene medications alone was 21.
Recently, the antileukotriene agents such as montelukast (Singulair) have been approved for allergic rhinitis.
Antileukotriene medications can help control asthma symptoms brought about by various triggers, including cold air.
Figure 49: Antileukotriene sales in the seven major markets by indication ($ billion), 2006-2019 121
Only five used anti-inflammatory medications (four on inhaled corticosteroids, one on the antileukotriene zafirlukast).
3) The newest of these are antileukotriene drugs and anti-immunoglobulin E monoclonal antibodies.
We retrospectively reviewed the charts of all ATD patients enrolled in the otolaryngology clinic at the Medical College of Wisconsin who had received antileukotriene therapy.