antiinflammatory drug


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antiinflammatory drug 

A drug which inhibits or suppresses most inflammatory responses of an allergic, bacterial, traumatic or anaphylactic origin, as well as being immunosuppressant. They include the corticosteroids (e.g. betamethasone, dexamethasone, fluorometholone, hydrocortisone acetate, loteprednol etabonate, prednisolone, rimexolone, triamcinolone). They are sometimes combined with an antibiotic drug (e.g. betamethasone combined with neomycin or sulfacetamide, dexamethasone combined with neomycin or polymyxin B). Corticosteroids have side effects, such as enhancing the activity of herpes simplex virus, fungal overgrowth, raising intraocular pressure or cataract formation.There are other antiinflammatory drugs that are non-steroidal (NSAID) and have little toxicity. They act mainly by blocking prostaglandin synthesis. These include diclofenac sodium, flurbiprofen sodium, indomethacin, ketorolac, nepafenac and oxyphenbutazone. See immunosuppressants; steroid.
References in periodicals archive ?
Similarly nonsteroid antiinflammatory drugs are at times contraindicated because the renal function is not fully mature in the early years of life.1416
(%), n = 43 (%), n = 14 (%), n = 100 Celiac disease 4 (9) 3 (21) 18 (18) Tropical sprue 1 (2) 0 (0) 1 (1) Helicobacter 0 (0) 0 (0) 6 (6) pylori Bacterial 2 (5) 0 (0) 3 (3) overgrowth NSAID use 6 (14) 0 (0) 8 (8) Inflammatory 5 (12) 0 (0) 8 (8) bowel disease Autoimmune 6 (14) 0 (0) 6 (6) conditions Infection 0 (0) 0 (0) 0 (0) Unexplained 3 (7) 3 (21) 26 (26) Irritable bowel 4 (9) 2 (14) 20 (20) syndrome Other 12 (28) 6 (43) 4 (4) Abbreviation: NSAID, nonsteroidal antiinflammatory drugs.
A recent series of studies suggests, however, that the nonacetylated salicylates, an older class of antiinflammatory drugs infrequently used today, show promise as potential new treatments for diabetes.
N-terminal pro-B-type natriuretic peptide concentrations predict the risk of cardiovascular adverse events from antiinflammatory drugs: a pilot trial.
Treatment of knee osteoarthritis: Relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic.
An emergency summit in Brussels, attended by seven member states, also agreed to test for "bute" - a powerful horse antiinflammatory drug which could pose a health risk if passed on to humans.
[5] Nonstandard abbreviations: coxib, cyclooxygenase-2 inhibitor; tNSAID, traditional nonsteroidal antiinflammatory drug; BNP, B-type natriuretic peptide; NT-proBNP, N-terminal proBNP; N-AE, cardiovascular adverse event; OA, osteoarthritis.
The company has introduced several abbreviated new drug applications (ANDAs), including Ascomp with codeine, a generic version of Novartis Pharmaceuticals Corp.'s pain reliever Fiorinal with codeine; methylprednisolone, a generic equivalent to Pharmacia's antiinflammatory drug Medrol; prochlorperazine, the generic version of GlaxoSmithKline PLC's Compazine; butalbital, acetaminophen, caffeine and codeine phosphate, the generic version of Novartis' Fioricet with codeine; and folic acid, 1 mg.
-- Celecoxib is safe for short-term use in ulcerative colitis patients who are in remission and on maintenance therapy, and who require treatment with a nonsteroidal antiinflammatory drug for arthritis or other conditions, a randomized controlled trial suggests.
Your doctor has prescribed you ibuprofen which is a non-steroidal antiinflammatory drug (NSAID).
Six weeks before, he had received for 3 days gluteal injections with kebusone (an intramuscular nonsteriodal antiinflammatory drug [NSAID]) for acute lower back pain.
alliacea root extract also presented a significant analgesic effect, at least in the experimental model used., as expected for an antiinflammatory drug. Indeed, the analgesic effect of the extract was less potent than the prototype drug acetylsalicilic acid.