antiinflammatory drug


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antiinflammatory drug 

A drug which inhibits or suppresses most inflammatory responses of an allergic, bacterial, traumatic or anaphylactic origin, as well as being immunosuppressant. They include the corticosteroids (e.g. betamethasone, dexamethasone, fluorometholone, hydrocortisone acetate, loteprednol etabonate, prednisolone, rimexolone, triamcinolone). They are sometimes combined with an antibiotic drug (e.g. betamethasone combined with neomycin or sulfacetamide, dexamethasone combined with neomycin or polymyxin B). Corticosteroids have side effects, such as enhancing the activity of herpes simplex virus, fungal overgrowth, raising intraocular pressure or cataract formation.There are other antiinflammatory drugs that are non-steroidal (NSAID) and have little toxicity. They act mainly by blocking prostaglandin synthesis. These include diclofenac sodium, flurbiprofen sodium, indomethacin, ketorolac, nepafenac and oxyphenbutazone. See immunosuppressants; steroid.
References in periodicals archive ?
Similarly nonsteroid antiinflammatory drugs are at times contraindicated because the renal function is not fully mature in the early years of life.
n = 43 (%), n = 14 (%), n = 100 Celiac disease 4 (9) 3 (21) 18 (18) Tropical sprue 1 (2) 0 (0) 1 (1) Helicobacter 0 (0) 0 (0) 6 (6) pylori Bacterial 2 (5) 0 (0) 3 (3) overgrowth NSAID use 6 (14) 0 (0) 8 (8) Inflammatory 5 (12) 0 (0) 8 (8) bowel disease Autoimmune 6 (14) 0 (0) 6 (6) conditions Infection 0 (0) 0 (0) 0 (0) Unexplained 3 (7) 3 (21) 26 (26) Irritable bowel 4 (9) 2 (14) 20 (20) syndrome Other 12 (28) 6 (43) 4 (4) Abbreviation: NSAID, nonsteroidal antiinflammatory drugs.
A recent series of studies suggests, however, that the nonacetylated salicylates, an older class of antiinflammatory drugs infrequently used today, show promise as potential new treatments for diabetes.
Treatment of knee osteoarthritis: Relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic.
If uric acid is reduced too quickly, acute gout is likely to recur, so an antiinflammatory drug or colchicine must also be given for the first three to six months of treatment with allopurinol or probenecid.
Six weeks before, he had received for 3 days gluteal injections with kebusone (an intramuscular nonsteriodal antiinflammatory drug [NSAID]) for acute lower back pain.
capsules, is an antiinflammatory drug with analgesic and antipyretic properties.
Used in combination with the standard antiinflammatory drug methotrexate, it improves remission rates six-fold.
Researchers at Queen's University in Belfast have developed an antiinflammatory drug which may be tested on patients in just two years.
Stewards probing the death of Jason Oliver, brother of Melbourne Cupwinning jockey Damien, have banned trainer Steve Wolfe for two years after it emerged the horse involved in the fatal fall later failed a test for an antiinflammatory drug.
7m in the UK last year, is an orallyadministered once-a-day version of the non-steroidal antiinflammatory drug, diclofenac, used to treat arthritis and other muscularskeletal disorders.
A non-steroidal antiinflammatory drug (indomethacin), will quell the inflammation around the joint quickly, and a 'cage' over the affected foot will stop bedclothes irritating it.