antiinflammatory drug


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antiinflammatory drug 

A drug which inhibits or suppresses most inflammatory responses of an allergic, bacterial, traumatic or anaphylactic origin, as well as being immunosuppressant. They include the corticosteroids (e.g. betamethasone, dexamethasone, fluorometholone, hydrocortisone acetate, loteprednol etabonate, prednisolone, rimexolone, triamcinolone). They are sometimes combined with an antibiotic drug (e.g. betamethasone combined with neomycin or sulfacetamide, dexamethasone combined with neomycin or polymyxin B). Corticosteroids have side effects, such as enhancing the activity of herpes simplex virus, fungal overgrowth, raising intraocular pressure or cataract formation.There are other antiinflammatory drugs that are non-steroidal (NSAID) and have little toxicity. They act mainly by blocking prostaglandin synthesis. These include diclofenac sodium, flurbiprofen sodium, indomethacin, ketorolac, nepafenac and oxyphenbutazone. See immunosuppressants; steroid.
References in periodicals archive ?
n = 43 (%), n = 14 (%), n = 100 Celiac disease 4 (9) 3 (21) 18 (18) Tropical sprue 1 (2) 0 (0) 1 (1) Helicobacter 0 (0) 0 (0) 6 (6) pylori Bacterial 2 (5) 0 (0) 3 (3) overgrowth NSAID use 6 (14) 0 (0) 8 (8) Inflammatory 5 (12) 0 (0) 8 (8) bowel disease Autoimmune 6 (14) 0 (0) 6 (6) conditions Infection 0 (0) 0 (0) 0 (0) Unexplained 3 (7) 3 (21) 26 (26) Irritable bowel 4 (9) 2 (14) 20 (20) syndrome Other 12 (28) 6 (43) 4 (4) Abbreviation: NSAID, nonsteroidal antiinflammatory drugs.
Toward an epidemiology of gastropathy associated with nonsteroidal antiinflammatory drug use.
Leslie Thomas suffered side effects including fits and a collapsed colon after testing antiinflammatory drug Vioxx in 2003.
These are treated mainly with non-steroidal antiinflammatory drugs (NSAIDS).
FDA Strengthens Warning that Non-Aspirin Nonsteroidal Antiinflammatory Drugs (NSAIDs) can Cause Heart Attacks or Strokes.
Most of the currently used analgesic drugs fall into the categories of opioids and nonsteroidal antiinflammatory drugs such as COX-2 inhibitors.
The Co Antrim star, 32, took "toxic amounts" of antiinflammatory drugs while on tour with The Sound of Music to reduce pain and swelling on her vocal cords after a throat operation.
The researchers investigated CDSCO approvals for and availability of oral Fixed Dose Combination (FDC) drugs in four therapeutic areas: analgesia (non-steroidal antiinflammatory drugs (NSAIDs), diabetes (metformin), depression/anxiety (anti-depressants/ benzodiazepines), and psychosis (antipsychotics).
She said the research study provided students the latest knowledge on antiinflammatory drugs.
There is hence a need to develop good antiinflammatory drugs with minimum side effects.