Based on the results obtained, few studies isolated the bioactive compounds to be further analyzed for the antiinflammatory
activity such as flavonoids (boesenbergin A, eupatorin, and sinensetin), coumarins (scopoletin and scoparone), triterpenoids (dammara-20,24-dien-3-one and 24-hydroxydammara-20,25-dien-3-one), steroids (cucurbitacin E), curcuminoids (monodemethoxycurcumin and bisdemethoxycurcumin), benzophenones (garsubellin A and garcinielliptin oxide), cinnamic acid (ethyl-p-methoxycinnamate), alkaloids (kokusaginine), benzene (p-O-geranylcoumaric acid), 4-[(20-O-acetyl-[alpha]-L-rhamnosyloxy)benzyl]isothiocyanate, 4-[(30-O-acetyl-[alpha]-L-rhamnosyloxy)benzyl]isothiocyanate, and 4-[(40-O-acetyl-[alpha]-L-rhamnosyloxy)benzyl]isothiocyanate [28, 30, 32, 33, 35, 38, 41, 45-47].
Being a privileged scaffold, coumarins are reported to have bioactivities such as anticoagulant , anti-HIV [4, 5], antioxidant [6, 7], antibacterial , antiinflammatory
[9, 10], anticancer , and dyslipidemic  activities.
Carrageenan-induced inflammation in the rat paw is a classical model of edema formation and hyperalgesia that has been extensively used in the development of nonsteroidal antiinflammatory
drugs and selective cyclooxygenase-2 (COX-2) inhibitors.
The value of stained proinflammatory and antiinflammatory
mediators was determined by the formula: stained cells/stained cells of control x 100.
(10.) Rathee P, Choudhary H, Rathee S, Rathee D, Kumar V; Mechanism of action of flavonoids as antiinflammatory
agents; A review.
The pentacyclic triterpenes reported previous for antiinflammatory
and antipyretic activities in vitro as well in vivo (Souza et al., 2014; Geetha and Varalakshmi, 2001; Safayhi and Sailer, 1997; Aguirre et al., 2006; Banno et al., 2006; Otuki et al., 2005).
There would be the double effect of protection from gastrointestinal side effects plus enhanced antiinflammatory
drugs available without a prescription include ibuprofen (Advil[TM], Motrin[TM], and generic brands) and naproxen (Aleve[TM] and generic brands).
recently reported the results of a population-based, case-control study regarding risk factors for pediatric invasive group A streptococcal (GAS) infection (1), noting that the "new" use of nonsteroidal antiinflammatory
drugs (NSAIDs), defined as NSAID use <2 weeks before diagnosis, was associated with invasive GAS infection, whereas self-defined "regular" NSAID use was not.
Instead, drug companies have concentrated on aspirin, ibuprofen, cyclo-oxygenase-2 inhibitors, and other antiinflammatory
drugs that block a single biochemical pathway but don't protect EETs.
Dahmen, et al., Boswellic Acid, a Potent Antiinflammatory
Drug, Inhibits Rejection to the Same Extent as High Dose Steroids, Transplant Proc., 33, 539 (2001); H.P.
Carrageenan-induced oedema in hind paw of rat as an assay for antiinflammatory