antihypertensive

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antihypertensive

 [an″te-, an″ti-hi″per-ten´siv]
effective against hypertension.
antihypertensive agent an agent that reduces high blood pressure; there are many different types of drugs that do this. diuretics inhibit the reabsorption of sodium in the renal tubules, causing an increase in urinary excretion of sodium and a decrease in the plasma volume and extracellular fluid volume. Drugs that act on adrenergic control of blood pressure include beta-adrenergic blocking agents such as propranolol, which act at beta-adrenergic receptors in the heart and kidneys to reduce cardiac output and renin secretion, and others such as methyldopa that act on alpha-adrenergic mechanisms in the central or sympathetic nervous system to reduce peripheral vascular resistance. vasodilators act directly on the arterioles to produce the same effect. Almost every case of hypertension can be controlled by one of these drugs or a combination of them. The proper combination is determined by the response of the individual patient. In some cases several drugs must be tried before the right combination is found.
Patient Education. Instruction of the patient and significant others is an essential part of antihypertensive therapy. Learning objectives are based on the patient's particular regimen of drug therapy, allowance of sodium intake, and other dietary restrictions, such as a low-calorie diet to combat obesity.

Some antihypertensive drugs can produce acute hypotensive reactions. The patient will need to know how to prevent a hypotensive reaction and what measures to take should such a reaction occur.

Prevention of a hypotensive reaction includes avoiding hot baths and sudden immobility after exercise, both of which promote vasodilation and a lowering of arterial pressure. The patient also should be aware of the effect of sudden changes in position that can precipitate an attack of orthostatic hypotension. Pooling of blood in the lower limbs can divert it from the brain and other vital organs. This can sometimes be avoided by moving about frequently instead of standing motionless for long periods of time. Elastic stockings also help promote venous return from the legs and help prevent fainting from decreased cerebral blood supply.

Acute hypotension can be serious, but milder hypotensive reactions with faintness and weakness can be relieved at home if the patient lies down and elevates his lower extremities above the level of his head and flexes the thigh muscles to encourage the flow of blood from his feet and legs to his brain.

The patient on a diuretic that is not potassium-sparing will need instruction on the symptoms of potassium deficit, how to avoid potassium depletion, and when to notify the doctor should hypokalemia occur.

Limitation of sodium intake can be very confusing and emotionally stressful to the uninstructed patient. In order to comply with the prescribed restriction of sodium the patient will need to know about satisfying substitutes and alternative seasonings for food, to be aware of the necessity of reading labels carefully when buying prepared food and over-the-counter medications, and to recognize the relationship between sodium and high blood pressure and the reasons why high sodium intake is harmful to health and well-being.

an·ti·hy·per·ten·sive

(an'tē-hī-per-ten'siv),
Indicating a drug or mode of treatment that reduces the blood pressure of hypertensive patients.

antihypertensive

(ăn′tē-hī′pər-tĕn′sĭv, ăn′tī-)
adj.
Reducing or controlling high blood pressure.
n.
An antihypertensive drug.

antihypertensive

adjective Referring to an agent or mechanism that counters hypertension.

noun An agent used to manage hypertension.

antihypertensive

adjective Referring to an agent or mechanism that reduces HTN noun An agent used to manage HTN

an·ti·hy·per·ten·sive

(an'tē-hī-pĕr-ten'siv)
Indicating a drug or mode of treatment that reduces the blood pressure of people with hypertension.

antihypertensive

1. Acting against high blood pressure (HYPERTENSION).
2. A drug used in the treatment of high blood pressure.

Antihypertensive

Used to describe drugs or treatments designed to control hypertension, or high blood pressure.
Mentioned in: Hyperaldosteronism

an·ti·hy·per·ten·sive

(an'tē-hī-pĕr-ten'siv)
Indicating a drug or treatment that reduces the blood pressure of hypertensive patients.
References in periodicals archive ?
* The goal of rapid-acting antihypertensive agents should be to achieve a BP of 140-150/90-100 mmHg.
In consideration of the restricted time window available for alteplase treatment as well as the potential for improved patient outcomes with earlier alteplase administration, it would be valuable to determine if the required blood pressure targets could be attained more rapidly with the use of specific antihypertensive agents. This study aimed to compare the antihypertensive effects of labetalol, nicardipine, and hydralazine in this patient population.
ecause sildenafil is a mixed arterial venous dilator (Jackson et al., 1999), and many antihypertensive agents exhibit irect or indirect vasodilating properties, it was important to determine whether treatment with sildenafil might potentiate the decrease in blood pressure achieved with the antihypertensive agents.
See Table 1 for some of the common side effects associated with widely used antihypertensive agents.
(22) While it may not be necessary to check whether all patients have obtained their prescription, it may be useful for subgroups of patients, such as those who have received a new diagnosis, whose disease is poorly controlled, who are prescribed new antihypertensive agents, or who are otherwise thought to be nonadherent.
Selection of an optimum antihypertensive agent is based on the patient's clinical status, age, volume status, coexisting medical conditions, presenting complications, end-organ compromise and pharmacodynamic effects of the drug.[6,11] Agents from nine different classes are available to choose from (Table 1).
* the side effect profile of antihypertensive agents, including orthostatic hypotension and the possibility of exacerbating an already heightened risk of falls; and
There have been no randomized, controlled trials of other antihypertensive agents in pregnancy, but anecdotes and case reports suggest that other [beta]-blockers and diltiazem are effective and may be used, he said.
Yet questions have persisted about whether the choice of initial antihypertensive agent in patients with metabolic syndrome warrants special consideration.
Tokyo, Japan, Aug 8, 2005 - (JCNN) - Sankyo announced on August 5 that it has signed a licensing agreement with Schering-Plough for its proprietary antihypertensive agent, olmesartan, an angiotensin II receptor blocker.
Patients were randomized to receive either valsartan or amlodipine as their first-line antihypertensive agent. After a run-in phase, patients received valsartan 80 mg/day, titrating to 160 mg/day after 1 week of treatment, or amlodipine 5 mg/day, titrating to 10 mg/day.
Revenue amounted to JPY256.4bn, up 12.9% year-on-year, mainly reflecting higher sales of Daiichi's antihypertensive agent olmesartan and an 84.7% leap in Ranbaxy's sales to JPY54.8bn.