1) HR positive breast cancer exhibits a favorable response to antihormone
therapies such as selective estrogen receptor modulators (SERMs) and aromatase inhibitors (Als).
It is becoming apparent that the inappropriate activation of growth factor signalling pathways plays a prominent role in the promotion of antihormone
failure in breast cancer cells where bi-directional cross-talk between oestrogen receptor and growth factor signalling pathways can sustain tumour growth in the presence of these agents.
Ongoing studies with active patient enrolling: - Phase II study comparing the radioactive drug, samarium with or without PROSTVAC(TM) therapy in men with metastatic prostate cancer - Phase II study comparing antihormone
therapy (flutamide) with or without PROSTVAC(TM) therapy in men with non-metastatic prostate cancer Ongoing studies with enrolment completed: - Phase II study investigating PROSTVAC(TM) in men with PSA progress after local therapy (surgery and/or radiation) - Phase I dose-escalation, combination study with PROSTVAC(TM) and MDX-010 (CTL4-antibody) in men with metastatic prostate cancer - Phase I study investigating PROSTVAC(TM) by intraprostatic injection in patients with progressive or locally recurrent prostate cancer
For example, estrogen receptor status is not only prognostic and predictive of response to antihormone
therapy, but also predictive of response to chemotherapy (the presence of the estrogen receptor is associated with less benefit from chemotherapy).
On October 25, 1988, Roussel-UCLAF announced suspension of distribution in France and elsewhere due to "French and foreign public opinion and the controversy raised by the possibility of using the antihormone
mifepristone (RU 486) to voluntarily interrupt pregnancy.
Tamoxifen, an antihormone
drug prescribed for postbreast surgery, costs approximately $75 a week to use, enthusiastically recommended by the attending physician for a five-year period: a $20,000 drug bill that is only part of the postperative treatment
Whether the diagnosis is made early for an in situ lesion or late for a metastatic tumor, recommended treatment nearly always involves a combination of surgery, radiation, chemotherapy, and antihormone
On the constituents of medicinal plants with hormone and antihormone
Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone
Although many estrogen receptor-positive breast cancers initially respond to antihormones
drugs, responses are commonly incomplete when resistance ultimately emerging.
Hormetic effects of hormones, antihormones
, and antidepressants on cancer cell growth in culture: in vivo correlates.
By binding to gonadal cells, these antagonistic antihormones
block activity by well-known forms of FSH, thereby disrupting normal hormone secretion.