antihormone

antihormone

 [an″te-hor´mōn]
a substance that counteracts a hormone.

antihormone

(1) An obsolete, nonspecific term for any agent that inhibits or counteracts the action of a hormone. 
(2) Chalone.

antihormone

Endocrinology A natural or synthetic analogue of a hormone–eg, FSH, LH, which binds to the hormone's receptor, blocking its activity. See B/I ratio.

an·ti·hor·mone

(an'tē-hōr'mōn)
Any substance demonstrable in serum that inhibits or prevents the usual effects of certain hormones, e.g., specific antibodies.

antihormone

a substance, usually antibody, that counteracts a hormone. It is produced in animals after repeated injections of a hormone or hormone-bearing protein. Further doses of the hormone may result in the neutralization of the hormone, in neutralization of the patient's own hormone, or in stimulation of an attack of allergy or anaphylaxis.
References in periodicals archive ?
1) HR positive breast cancer exhibits a favorable response to antihormone therapies such as selective estrogen receptor modulators (SERMs) and aromatase inhibitors (Als).
It is becoming apparent that the inappropriate activation of growth factor signalling pathways plays a prominent role in the promotion of antihormone failure in breast cancer cells where bi-directional cross-talk between oestrogen receptor and growth factor signalling pathways can sustain tumour growth in the presence of these agents.
Ongoing studies with active patient enrolling: - Phase II study comparing the radioactive drug, samarium with or without PROSTVAC(TM) therapy in men with metastatic prostate cancer - Phase II study comparing antihormone therapy (flutamide) with or without PROSTVAC(TM) therapy in men with non-metastatic prostate cancer Ongoing studies with enrolment completed: - Phase II study investigating PROSTVAC(TM) in men with PSA progress after local therapy (surgery and/or radiation) - Phase I dose-escalation, combination study with PROSTVAC(TM) and MDX-010 (CTL4-antibody) in men with metastatic prostate cancer - Phase I study investigating PROSTVAC(TM) by intraprostatic injection in patients with progressive or locally recurrent prostate cancer
For example, estrogen receptor status is not only prognostic and predictive of response to antihormone therapy, but also predictive of response to chemotherapy (the presence of the estrogen receptor is associated with less benefit from chemotherapy).
On October 25, 1988, Roussel-UCLAF announced suspension of distribution in France and elsewhere due to "French and foreign public opinion and the controversy raised by the possibility of using the antihormone mifepristone (RU 486) to voluntarily interrupt pregnancy.
Tamoxifen, an antihormone drug prescribed for postbreast surgery, costs approximately $75 a week to use, enthusiastically recommended by the attending physician for a five-year period: a $20,000 drug bill that is only part of the postperative treatment
Whether the diagnosis is made early for an in situ lesion or late for a metastatic tumor, recommended treatment nearly always involves a combination of surgery, radiation, chemotherapy, and antihormone therapies.
On the constituents of medicinal plants with hormone and antihormone like action.
Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone.
Although many estrogen receptor-positive breast cancers initially respond to antihormones drugs, responses are commonly incomplete when resistance ultimately emerging.
Hormetic effects of hormones, antihormones, and antidepressants on cancer cell growth in culture: in vivo correlates.
By binding to gonadal cells, these antagonistic antihormones block activity by well-known forms of FSH, thereby disrupting normal hormone secretion.