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an antibody directed against gamma globulin.
antiglobulin test (AGT) Coombs' test.
a test for antibodies, the so-called anti-human globulin test using either the direct or indirect Coombs tests.
Synonym(s): antiglobulin test
a test for the presence of antibodies that coat and damage erythrocytes as a result of any of several diseases or conditions. The test can detect Rh antibodies in maternal blood and is used to anticipate hemolytic disease in the newborn. It is also used to diagnose and screen for autoimmune hemolytic anemias and to determine the compatibility of blood types. When exposed to a sample of the patient's serum, the antiglobulin serum causes agglutination if human globulin antibody or its complement is present. Also called Coombs' test.
an·ti·glob·u·lin test(an'tē-glob'yū-lin test)
Laboratory assessment to detect red blood cell antibodies in patient serum (indirect) or immunoglobulin bound to the surface of the red blood cell (direct).
Coombs,Robin R.A., English veterinarian and immunologist, 1921–.
Coombs serum - serum from a rabbit or other animal previously immunized with purified human globulin to prepare antibodies directed against IgG and complement. Synonym(s): antihuman globulin
Coombs test - a test for antibodies, the so-called antihuman globulin test, using either the direct or indirect Coombs tests. Synonym(s): antiglobulin test
direct Coombs test - a test for detecting sensitized erythrocytes in erythroblastosis fetalis and in cases of acquired immune hemolytic anemia.
Gell and Coombs reaction - see under Gell
indirect Coombs test - a test routinely performed in cross-matching blood or in the investigation of transfusion reaction.
an antibody to a heterologous antibody, such as goat antihorse IgG antibody, as used in the Coombs test, ELISA, immunofluorescence or other assays.
see coombs tests.