Evaluation of the clinical utility of maternal alloantibody screening as a surrogate to antiglobulin
crossmatch procedures in resource limited settings.
One case (0.86%) of 116 SCD patients in the nonalloimmunized patients developed autoantibody as revealed by positive polyclonal autocontrol and direct antiglobulin
Detection of alloantibodies using a sensitive antiglobulin
microtoxicity test: identification of low levels of pre-formed antibodies in accelerated allograft rejection.
Antibody-mediated All patients with positive direct antiglobulin
hemolysis test where an alternative cause could not be found.
Other labs were remarkable for elevated LDH (2009 mg/dL), reticulocytosis (absolute reticulocyte count: 354,576 cells/[mm.sup.3]), and a positive direct antiglobulin
test suggesting a delayed hemolytic transfusion reaction.
2 Direct antiglobulin
Ab test (direct Coomb test) was done to evaluate for hemolytic anemia.
In a study, infants were recognized to be at risk of developing hemolytic disease secondary to ABO incompatibility, when they had a positive direct antiglobulin
Laboratory investigations were parasitologic (thick and thin blood smears), hematologic (differential blood count), and biochemical (haptoglobin, lactate dehydrogenase [LDH], C-reactive protein, potassium, and sodium levels and renal and liver function tests) examinations; screening for glucose-6-phosphate dehydrogenase deficiency; and immunohematologic examinations (direct and indirect antiglobulin
test, including testing with enzyme-treated erythrocytes).
* Blood group incompatibility with positive direct antiglobulin
test, other known hemolytic disease (e.g.: G6PD deficiency).
Previously used methods are all obsolete, with only the mixed antiglobulin
reaction (MAR) test and the immunobead test (IBT) being used to detect the presence of ASA (World Health Organization, 1999).
A Turkish study concluded that reticulocyte count, the presence of a sibling with neonatal jaundice and a positive direct antiglobulin
test were good predictors for the development of significant hyperbilirubinemia and a serum bilirubin levels of 4 mg/dL and 6 mg/dL at six hours of life are good predictors of severe hyperbilirubinemia.
Blood grouping and direct antiglobulin
test was performed in these patients.