antigliadin antibody


Also found in: Dictionary, Thesaurus, Encyclopedia.

antigliadin antibody

Immunology Gliadins are a class of proteins found in the gluten of wheat and rye grains; in genetically susceptible individuals, α-gliadins evoke production of IgA and IgG antibodies in Pts with celiac disease, resulting in a malabsorption syndrome–celiac sprue or gluten-sensitive enteropathy–GSE, and possibly dermatitis herpetiformis–DH Ref range IgA < 31 AU, negative; 32–39 AU, equivocal; > 39 positive; IgG < 89 AU, negative; 90–110 AU, equivocal; > 110 positive. See Celiac disease, Gluten.

antigliadin antibody

An antibody formed against the gluten in wheat, found in the serum of people with celiac sprue.
See also: antibody
References in periodicals archive ?
Antigliadin antibody testing is no longer recommended because of low sensitivity and specificity.
Four serum antibody assays may serve as a first-step diagnostic tool to identify biopsy candidates: immunoglobulin A tissue transglutaminase (IgA tTG), IgA endomysial antibody (IgA EMA), IgA antigliadin antibody (IgA AGA), and IgG antigliadin antibody (IgG AGA).
When the histological criteria of coeliac disease are used as the gold standard, IgG, antigliadin antibody has low specificity.