There can be an absence of antigenemia and antigenuria
in immunocompromised patients with histoplasmosis, and therefore histopathology and cultures remain the gold standards for making a definitive diagnosis.
Development and evaluation of an enzyme-linked immunosorbent assay to detect Histoplasma capsulatum antigenuria in immunocompromised patients.
Evaluation of the IMMY ALPHA Histoplasma antigen enzyme immunoassay for diagnosis of histoplasmosis marked by antigenuria. Clin Vaccine Immunol.
can be detected as early as one day after onset of symptoms and persists for days to weeks.
Consequently a positive result in the ELISA for IgM should be considered as presumptive and confirmation should be done by highly specific antigenuria
detection or seroconversion (3).
Galactomannon antigenemia antigenuria
in aspergillosis: studies in patients and experimentally infected rabbits.
The results indicated that antigenuria
was detectable in 41 of the 45 specimens (91%; index value greater than 1) with index values ranging from 1 to 1.4(26.7%), 1.41 to 1.8 (60%), and 1.81 to 2.1 (4.4%).
Based on multicenter evaluation of MVista Histoplasma antigen EIA of 218 patients with histoplasmosis, antigenuria
was detected in 92% of PDH (progressive disseminated histoplasmosis) cases, including 95% of those with AIDS, 93% of those with other immunocompromising conditions, and 73% of patients not known to be immunocompromised.