Systemic immunotherapies have failed to demonstrate significant clinical activity due to a tumor microenvironment characterized by low tumor antigenicity
, limited infiltration of effector cells, and several processes that suppress immune cell function.
The 38 proteins with high potential were ranked based on a cumulative score that was derived from protein antigenicity
, density of MHC-I and MHC-II epitopes, MHC allele coverage, and B-cell epitope density scores (Table 1).
Kolaskar and Tongaonkar antigenicity
scale for prediction of antigenic determinants in ACTTS protein in ARC (A), AWR (B) and AYC (C).
In Section 2, we showed that the antigenicity
of the tumor ([beta]) is a key parameter.
The second region registers the highest peak of antigenicity
and integrates a greater amount of amino acids from [Ser.sub.374]-[Arg.sub.420], 47 amino acids in total, being located in the opposite side to the active site and in a zone highly exposed to the solvent, as can be observed in Figure 7(1B).
Plot statistics DRB1*0701 DRB1*0901 % residues in favourable regions 89.5 89.2 % residues in additional residue regions 9.9 10.8 % residues in generously regions 0.0 0.0 % residues in disallowed regions 0.6 0.0 % of nonproline and nonglycine residues 100.00 100.00 Plot statistics HLA-B39 HLA-B58 % residues in favourable regions 92.8 92.0 % residues in additional residue regions 6.6 7.7 % residues in generously regions 0.6 0.3 % residues in disallowed regions 0.0 0.0 % of nonproline and nonglycine residues 100.00 100.00 Table 2: Comparison of antigenicity
of antigenic proteins of Mycobacterium spp.
Glycosylation of the HA gene is important for neutralization of the antigenic sites, (25) proper folding of the proteins, and has big influence on the antigenicity
and immunogenicity of the HA glycoprotein.
Anaphylaxis may be triggered by multiple agents, one of this is the hydatid cyst due to its high antigenicity
. Allergic reaction during hydatid cyst operation can occur due to interaction of an allergen (hydatid fluid) with specific immunoglobulin E (IgE) antibodies, which are present on mast cells and basophils in sensitized individuals.
Collagen is regarded as one of the most useful biomaterials due to its excellent biocompatibility, biodegradability and weak antigenicity
Special attention has been given to collagen-based hydrogels for drug delivery applications [1-5], but they suffer many drawbacks such as rapid degradation, poor mechanical properties, and possible antigenicity
These data reinforce the close taxonomic relationships between the three mycobacterial species and demonstrate the antigenicity
of the new variants of mycobacterial glycopeptidolipids, whereas the second group has structures similar to those produced by the antigenic lipooligosaccharides of M.
In vivo use of gelatin has been successfully demonstrated by implantation in animal models, with results that suggest low toxicity and reduced antigenicity
relative to collagen [17, 18].