antigenic variation


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antigenic variation

successive changes in the surface ANTIGENS of certain MICROORGANISMS, resulting in a range of antigenically different forms. This can help a PATHOGEN, such as influenza virus, to avoid the host's immune defence system. See IMMUNITY.
References in periodicals archive ?
Mechanisms and molecular pathways underlying antigenic variation of Borreliahermsii variable major lipoprotein (Vmp) and B.
These multigene families are responsible for the antigenic variation of the parasite in natural infections which enables it to escape the host immune response for its survival resulting in prolonged chronic infections.
The virus undergoes antigenic variation year by year due to the selection of antigenic variants by immunological pressure of the hosts.
TABLE 1 Hemagglutination-inhibition titers of influenza B viruses [*] -- United States and worldwide, May-September 25, 2001 Antisera B/Sichuan/ B/Victoria/ B/Hong Kong/ Viral antigen 379/99 504/2000 6/2001 B/Yamagata/16/88 group viruses B/Sichuan/379/99 320 2560 20 B/Victoria/504/2000 320 2560 10 B/Victoria/2/87 group viruses B/Hong Kong/6/2001 [less than]10 20 1280 B/Hong Kong/22/2001 [less than]10 10 640 B/Hong Kong/ Viral antigen 22/2001 B/Yamagata/16/88 group viruses B/Sichuan/379/99 10 B/Victoria/504/2000 [less than]10 B/Victoria/2/87 group viruses B/Hong Kong/6/2001 640 B/Hong Kong/22/2001 640 (*)A fourfold difference in hemagglutination-inhibition titer betwen two viruses usually indicates antigenic variation between viruses.
The Evolution of Antigenic Variation in African Trypanosomes
In antigenic variation mechanism when a parasite e.
Finally, wepropose to exploit the extraordinary potential of trypanosomes for antigenic variation in order to produceSRA variants able to neutralize the pathogenic APOL1 variants.
Four hypervariable domains in this region, variable domains (VD) I-IV, are responsible for the large degree of antigenic variation in this gene.
The text blends classical and medical parasitology with more modern disciplines, discussing the molecular and immunological basis for pathogenesis, metabolic pathways, and antigenic variation for the protozoan pathogens.