antigenic determinant


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Related to antigenic determinant: hapten, Clonal selection

determinant

 [de-ter´mĭ-nant]
a factor that establishes the nature of an entity or event.
antigenic determinant a site on the surface of an antigen molecule to which a single antibody molecule binds; generally an antigen has several or many different antigenic determinants and reacts with many different antibodies. Called also epitope.
 Antigens contain antigenic determinants (epitopes) and antibodies contain antibody combining sites (paratopes). From Copstead and Banasik, 2000.
hidden determinant an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
immunogenic determinant the part of an immunogenic molecule that interacts with a helper T cell in triggering antibody production as opposed to the antigenic determinant or hapten, which interacts with B cells.

an·ti·gen·ic de·ter·mi·nant

the particular chemical group of a molecule that determines immunologic specificity.
Synonym(s): determinant group

an·ti·gen·ic de·ter·mi·nant

(an'ti-jen'ik dĕ-tĕr'mi-nănt)
The particular chemical group of a molecule that determines immunologic specificity.

antigenic determinant

A cluster of EPITOPES.

antigenic determinant

see EPITOPE.
References in periodicals archive ?
Woods, "Prediction of protein antigenic determinants from amino acid sequences," Proceedings of the National Academy of Sciences of the United States of America, vol.
The positions of the Asparagines (N) that were identified as potential N-glycosylation sites and which are a part of the reported antigenic determinants are highlighted in bold in Table 5 because this is a factor that may contribute to the induction of an immune response by both phytases [39].
As all the surface SGPs act as blood group antigenic determinants and receptor sites for viruses, bacteria and parasites, the presence of higher number of SGPs within the membrane of goat, buffalo and pig erythrocyte indicates the higher immunological response of the animals as compared to human.
Penicillin is metabolised into major (penicilloyl) and minor (penicilloate and penilloate) antigenic determinants. It is essential to test for both determinants as testing for only the major determinants would miss at least 10% of penicillinsensitive subjects.
This method is a solid-phase assay in which 2 monoclonal antibodies (6E6 and 8F8) are directed against 2 separate antigenic determinants on the ADAM12 molecule.
HLA II tg mice provide a powerful model for an exhaustive characterization and identification of the antigenic determinants on allergens.
Use of multiple antigenic peptides related to antigenic determinants of infectious bursal disease virus (IBDV) for detection of anti- IBDV-specific antibody in ELISA-quantitative comparison with native antigen for their use in serodiagnosis.
Using vesicular stomatitis virus and prostate and melanoma derived libraries, this is curative in mice and we have established its mechanisms and the key antigenic determinants (Nature Medicine, Nature Biotechnology).
At present mAbs represent the best available tools to study the role of nonneutralizing/interfering B-cell epitopes, giving their standardized behavior compared to polyclonal preparations (i.e., specific reactivity with individual antigenic determinants) and indeed the ideal probes for studying the spatial relationship or topography of viral targeted epitopes and their role in neutralization [87].
Human insulin has 2 antigenic determinants. One is the terminus of the B chain (6-9), and the other is the immunodominant A-chain loop, which comprises residues A8-A10 (10-13)).