antigen-presenting cell


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Related to antigen-presenting cell: dendritic cell, T cell

antigen-presenting cell

Abbreviation: APC
A cell that breaks down antigens and displays their fragments on surface receptors next to major histocompatibility complex molecules. This presentation is necessary for some T lymphocytes that are unable to recognize soluble antigens. Macrophages are the primary antigen-presenting cells, but B cells and dendritic cells also can act as APCs.
See: T cell; macrophage processing cell
See also: cell

antigen-presenting cell

A cell, such as a macrophage, a B cell or a dendritic cell, that presents processed antigenic peptides and MHC class II molecules to the T cell receptor on CD4 T cells.
References in periodicals archive ?
We investigated the identity of the immune infiltrate, revealing the presence of antigen-presenting cells by immunohistochemistry on paraffin embedded sections.
The binding of lymphocyte function-associated antigen-1 (LFA-1) with intercellular adhesion molecule-1 (ICAM-1) initiates the transendothelial migration of T cells to the paracortical region of draining lymph nodes, where both naive T cells and Tregs interact with antigen-presenting cells (APCs).
These NKT cells are able to identify and bind to self or nonself lipids/glycolipids through the expression of CD1d molecule on antigen-presenting cells after which they secrete several cytokines such as IL-12 and IFN-[gamma] for activation of other immune response [33].
Krummel calls the cells antigen-presenting CD103+ dendritic cells, and they make up fewer than 1 percent of all antigen-presenting cells, he said.
Dendritic cells (DCs) are the most important antigen-presenting cells (APCs) in the upstream of immunomodulatory pathway.
In the PLAT-03 trial, patients will receive "booster" infusions of a second T-cell product, called T antigen-presenting cells (T-APCs).
2) The influence of apoAI on adhesion of T cells to antigen-presenting cells;
The [CD8.sup.+] T cells can take plasma membrane fragments of antigen-presenting cells (APCs) via T-cell receptor (TCR) and antigen (Ag)/class I major histocompatibility complex (MHC), when these cells form an immunological synapse.
In fact, there is no clear answer to this question, although it would appear that among the important variables are the size of the protein, glycosylation status, biologic function (e.g., enzymatic activity), resistance to proteolytic digestion, overall immunogenicity and the way in which the protein is recognized, internalized, and processed by antigen-presenting cells, and the manner in which peptides are presented to responsive T lymphocytes (Aalberse 2000; Astwood et al.
The role of antigen-presenting cells in the regulation of allergen-specific T cell responses.
DCs are the most potent antigen-presenting cells linking innate and adaptive immune responses.
He also found that Plasmodium GPI would hyperactivate macrophages and antigen-presenting cells in the immune system, and cause red blood cells to adhere to blood vessels--all conditions associated with deadly cerebral malaria.