Chakraborty proposed that the chain of events that led a T cell to go forth and conquer involved a type of hysteresis; the response to signals from antigen-presenting cells
was based on recent encounters with other antigen-presenting cells
If the antigen-presenting cells
produce the peanut protein robustly enough, the responsibility for the immune response might shift away from the IgE antibodies and mast cells.
This study showed that the cigarette recruited antigen-presenting cells
(cells that orchestrate the immune system's response to antigens) as co-conspirators in the lung-destroying crime, using specific genes that regulate proteins in their deadly role.
The dynamics of helper and suppressor T cells and their interaction with antigen-presenting cells
could be modeled as a separate subsystem, or module, whose output served as input to the B-cell module.
The active immunotherapy approach many immunologists see as most promising involves using antigen-presenting cells
to induce tumor-specific T-cell responses in melanoma patients.
Scientists consider dendritic cells to be the most potent antigen-presenting cells
in the body.
A number of activated immune cells can infiltrate the synovium (including CD4+ T-cells, B-cells and antigen-presenting cells
such as dendritic cells and macrophages).
APX005M, a novel, humanized monoclonal antibody that stimulates the anti-tumor immune response in the tumor microenvironment through antigen-presenting cells
of the immune system, is engineered to selectively activate CD40 in tumor tissues, rather than broadly in the bloodstream like other CD40 agonists.
Immune cells known as antigen-presenting cells
need to activate T lymphocytes to trigger them to attack, but in cancer, cells called tumor-associated macrophages tell T lymphocytes to remain dormant, and also foster the development of blood vessels that feed the growing tumor.
ADXS-HPV is designed to infect antigen-presenting cells
and direct them to generate a powerful, cellular immune response to HPV E7, concluded the company.
The researchers found that one TLR, known as TLR8, triggered a strong immune response in antigen-presenting cells
, which are crucial for vaccine responses.
CTLA4Ig binds to CD80 and CD86 on antigen-presenting cells
, blocking the engagement of CD28 on T cells and preventing T-cell activation.