paratope

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Related to antigen-binding site: variable region, Surface immunoglobulin

determinant

 [de-ter´mĭ-nant]
a factor that establishes the nature of an entity or event.
antigenic determinant a site on the surface of an antigen molecule to which a single antibody molecule binds; generally an antigen has several or many different antigenic determinants and reacts with many different antibodies. Called also epitope.
 Antigens contain antigenic determinants (epitopes) and antibodies contain antibody combining sites (paratopes). From Copstead and Banasik, 2000.
hidden determinant an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
immunogenic determinant the part of an immunogenic molecule that interacts with a helper T cell in triggering antibody production as opposed to the antigenic determinant or hapten, which interacts with B cells.

par·a·tope

(par'ă-tōp),
That part of an antibody molecule composed of the variable regions of both the light and heavy chains that combine with the antigen.
[para- + -tope]

par·a·tope

(par'ă-tōp)
That part of an antibody molecule composed of the variable regions of both the light and heavy chains that combine with the antigen.
Synonym(s): antibody-combining site.
References in periodicals archive ?
The ability of MHC class II molecules to bind and present antigenic peptides depends on the amino acid composition of their antigen-binding sites. Amino acid substitutions of the peptide may influence the specificity of the immune response by altering the binding affinity for the MHC class II molecules.
Light chains attach to the antigen-binding sites of the heavy chains, forming complete antibodies.
"Some of these synthetic molecules recognize the antigen-binding sites of disease-specific antibodies well enough to pull them from blood samples, although they almost certainly don't bind as well as the native antigens.

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