antigen processing


Also found in: Dictionary, Thesaurus, Financial, Encyclopedia, Wikipedia.

antigen processing

The mechanism by which foreign antigens are taken into antigen-presenting cells (APCs) and broken up. Part of the antigen is then displayed (presented) on the surface of the APC next to a histocompatibility or self-antigen, activating T lymphocytes and cell-mediated immunity. T lymphocytes are unable to recognize or respond to most antigens without APC assistance.
See: antigen; macrophage processing; self
See also: processing
References in periodicals archive ?
Thus, if PRN exposure only partially interferes with antigen processing or presentation, its adverse effect may be masked under these in vitro assay conditions.
Antigen processing: where tumor-specific T-cell responses begin.
Such a low T-cell epitope discovery rate is due to the fact that we do not have adequate models for predicting antigen processing yet [68].
Jensen, "Recent advances in antigen processing and presentation," Nature Immunology, vol.
Kohlbacher, "Integrated modeling of the major events in the MHC class I antigen processing pathway," Protein Science, vol.
Cresswell, "Pathways of antigen processing," Annual Review of Immunology, vol.
Frierson Jr., "Relationship between HLA class I antigen processing machinery component expression and the clinicopathologic characteristics of bladder carcinomas," Cancer Immunology, Immunotherapy, vol.
HLA class I polymorphisms primarily concentrated in the peptide binding region (PBR) not only influence the features and repertoire of peptides presented to the cell surface but also affect their requirement on the PLC components for antigen processing and presentation [15-19].
Cresswell, "Mechanisms of MHC class I-restricted antigen processing," Annual Review of Immunology, vol.
Howard, "MHC class I molecules compete in the endoplasmic reticulum for access to transporter associated with antigen processing," The Journal of Immunology, vol.