antigen processing


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antigen processing

The mechanism by which foreign antigens are taken into antigen-presenting cells (APCs) and broken up. Part of the antigen is then displayed (presented) on the surface of the APC next to a histocompatibility or self-antigen, activating T lymphocytes and cell-mediated immunity. T lymphocytes are unable to recognize or respond to most antigens without APC assistance.
See: antigen; macrophage processing; self
See also: processing
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References in periodicals archive ?
Thus, if PRN exposure only partially interferes with antigen processing or presentation, its adverse effect may be masked under these in vitro assay conditions.
Antigen processing: where tumor-specific T-cell responses begin.
Propanil exposure induces delayed but sustained abrogation of cell-mediated immunity through direct interference with cytotoxic T-lymphocyte effectors
Such a low T-cell epitope discovery rate is due to the fact that we do not have adequate models for predicting antigen processing yet [68].
Jensen, "Recent advances in antigen processing and presentation," Nature Immunology, vol.
Kohlbacher, "Integrated modeling of the major events in the MHC class I antigen processing pathway," Protein Science, vol.
Cresswell, "Pathways of antigen processing," Annual Review of Immunology, vol.
Fundamentals and Methods for T- and B-Cell Epitope Prediction
Frierson Jr., "Relationship between HLA class I antigen processing machinery component expression and the clinicopathologic characteristics of bladder carcinomas," Cancer Immunology, Immunotherapy, vol.
The Pathophysiological Impact of HLA Class Ia and HLA-G Expression and Regulatory T Cells in Malignant Melanoma: A Review
HLA class I polymorphisms primarily concentrated in the peptide binding region (PBR) not only influence the features and repertoire of peptides presented to the cell surface but also affect their requirement on the PLC components for antigen processing and presentation [15-19].
Cresswell, "Mechanisms of MHC class I-restricted antigen processing," Annual Review of Immunology, vol.
Howard, "MHC class I molecules compete in the endoplasmic reticulum for access to transporter associated with antigen processing," The Journal of Immunology, vol.
A micropolymorphism altering the residue triad 97/114/156 determines the relative levels of tapasin independence and distinct peptide profiles for HLA-A*24 allotypes
Ploegh, "The known unknowns of antigen processing and presentation," Nature Reviews Immunology, vol.
Peptide-based vaccinology: experimental and computational approaches to target hypervariable viruses through the fine characterization of protective epitopes recognized by monoclonal antibodies and the identification of T-cell-activating peptides

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