antigen excess

Also found in: Dictionary, Thesaurus, Legal, Encyclopedia.

an·ti·gen ex·cess

1. in a precipitation test, the presence of uncombined antigen in excess of that required to combine with all of the antibody; precipitation may be inhibited because the presence of excess antigen gives rise to soluble antigen-antibody complexes;

2. in vivo, the resultant antigen-antibody interaction in such an antigen excess may give rise to immune complexes, which have a potential to induce cellular damage; could be tolerogenic.

an·ti·gen ex·cess

(an'ti-jen eks'es)

1. In a precipitation test, the presence of uncombined antigen above that required to combine with all of the antibody.

2. In vivo, the resultant antigen-antibody interaction in such an antigen excess may give rise to immune complexes, which have a potential to induce cellular damage.

Mentioned in ?

References in periodicals archive ?

The serum was retested with further dilutions to rule out antigen excess, and no antigen excess was detected.

Quantification of serum IgG subclasses by use of subclass-specific tryptic peptides and liquid chromatography-tandem mass spectrometry

WHAT IS THE PREVALENCE OF ANTIGEN EXCESS IN THE FLC ASSAY?

Sharply increased serum free light-chain concentrations after treatment for multiple myeloma

In conclusion, we have illustrated that antigen excess can cause falsely low serum FLC results with nephelometric techniques.

Risk of antigen excess in serum free light chain measurements

The manufacturer assay protocol for total [kappa] did not include a prereaction step to detect antigen excess.

Comparison of the sensitivity of 2 automated immunoassays with immunofixation electrophoresis for detecting urine Bence Jones proteins

200 cutoff value for the prozone check effectively detected all samples in which antigen excess caused falsely low microalbuminuric or normal values.

(Micro)albuminuria: antigen excess detection in the Roche Modular analyzer

We can recognize antigen excess by the appearance of two curved bands at the edges of an inner colorless zone indicating the excess antigen.

Rapid method for [[beta].sub.2]-transferrin in cerebrospinal fluid leakage using an automated immunofixation electrophoresis system

We used polyclonal free light chains to initially test for antigen excess and showed that the assay was robust.

Measurement of free light chains in Urine

The quoted upper limit for IgG before antigen excess is reached is 95 g/L.

Analytical performance of specific-protein assays on the Abbott Aeroset system

The Access Hybritech PSA assay did not demonstrate antigen excess up to 50 000 [micro]g/L PSA, and FPSA did not hook until >20 000 [micro]g/L.

Hybritech total and free prostate-specific antigen assays developed for the Beckman Coulter access automated chemiluminescent immunoassay system: a multicenter evaluation of analytical performance