antigen excess

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an·ti·gen ex·cess

1. in a precipitation test, the presence of uncombined antigen in excess of that required to combine with all of the antibody; precipitation may be inhibited because the presence of excess antigen gives rise to soluble antigen-antibody complexes;

2. in vivo, the resultant antigen-antibody interaction in such an antigen excess may give rise to immune complexes, which have a potential to induce cellular damage; could be tolerogenic.

an·ti·gen ex·cess

(an'ti-jen eks'es)

1. In a precipitation test, the presence of uncombined antigen above that required to combine with all of the antibody.

2. In vivo, the resultant antigen-antibody interaction in such an antigen excess may give rise to immune complexes, which have a potential to induce cellular damage.

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References in periodicals archive ?

If the sum of IgG1-4 differs by >20% from the total IgG concentration, the assays are repeated at higher dilutions to rule out antigen excess.

Quantification of serum IgG subclasses by use of subclass-specific tryptic peptides and liquid chromatography-tandem mass spectrometry

This experience prompted us to further investigate the incidence of serum FLC antigen excess.

Sharply increased serum free light-chain concentrations after treatment for multiple myeloma

0 mg/L), a total imprecision study (total CVs <10%), antigen excess detection (tested up to 50 g/L), analytical recovery near 100%, and parallelism between polyclonal and monoclonal FLCs within the analytical ranges.

Comparison of the sensitivity of 2 automated immunoassays with immunofixation electrophoresis for detecting urine Bence Jones proteins

In conclusion, an effective and efficient procedure for the detection of antigen excess could be included in the assay for urinary albumin on the Roche Modular analyzer and could eliminate the need for additional tests to prevent reporting of falsely low results from antigen excess.

(Micro)albuminuria: antigen excess detection in the Roche Modular analyzer

The quoted upper limit for IgG before antigen excess is reached is 95 g/L.

Analytical performance of specific-protein assays on the Abbott Aeroset system

Furthermore, this simple prozone detection method can be adapted to other nephelometric assays with the potential for erroneous results from antigen excess.

Dilution protocols for detection of hook effects/prozone phenomenon

Because of potential problems in the assay of MC, especially problems due to antigen excess (6), we compared the results of assays of non-MC-containing samples and of MC-containing samples separately, as well as the overall results (Fig.

Evaluation of proficiency survey results for serum immunoglobulins following the introduction of a new international reference material for human serum proteins

This led us to devise a new method with particle-enhanced turbidimetric inhibition, where antigen excess would not be a problem but good assay imprecision at the upper limit of the reference range could be achieved.

Development and validation of a particle-enhanced turbidimetric inhibition assay for urine albumin on the Dade aca[R] analyzer