antifungal agent


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antifungal agent

see ANTIMICROBIAL AGENT.

antifungal agent 

Any substance which destroys or prevents the growth of fungi. It is one of the antibiotic groups. There are several classes of antifungal drugs: Polyenes, which cause an increase in fungal cell wall permeability leading to its death. Examples: amphotericin B, natamycin, nystatin. Azoles, which act either by inhibiting the synthesis of ergosterol, a component of fungal cell wall or by causing direct wall damage. Examples: clotrimazole, econazole, fluconazole, itraconazole, ketoconazole, miconazole. Pyrimidines, which interfere with the normal function of fungal cells. Example: flucytosine. Syn antimycotic agent.
References in periodicals archive ?
The azole antifungal agents are classified as imidazoles (ketoconazole and miconazole) or triazoles (itraconazole and fluconazole) as determined by the number of nitrogens (either two or three respectively) in the five-membered azole ring (19).
No well-designed, comparative study was identified that showed any oral antifungal agent to be superior to terbinafine in the treatment of dermatophytic skin infections.
This is because the indiscriminate initiation of empiric antifungal agents may render them ineffective over time with the progression of fungal resistance.
Antifungal agents are either polyenes (nystatin and am-photericin B) or azoles which are classified into: imidazoles (clotrimazole, econazole, fenticonazole, isoconazole, ketocon-azole, miconazole, sulconazole, tioconazole); and triazoles (fluconazole, itraconazole).
Because they have a variety of useful properties, especially as antibacterial and antifungal agents, silver nanoparticles increasingly are being used in a wide variety of industrial and consumer products.
To overcome these problems, attempts have been made to incorporate the antifungal agents such as Zinc undecylenate, Nystatin, Fluconazole and Itraconazole to the resilient liners.
MIC endpoints were determined for nine antifungal agents: micafungin, caspofungin, flucytosine, posaconazole, voriconazole, itraconazole, fluconazole, anidulafungin and amphotericin B.
As a potent antifungal agent, PC945 is currently being developed for the treatment of Aspergillusinfections in patients with asthma, cystic fibrosis and following lung transplantation.
Kazunori Maebashi, Senior Project Manager at Meiji Seika Pharma will be presenting on "The Development of ME1111 at Meiji Seika," focusing on a novel class of antifungal agent which is under clinical development as a topical onychomycosis treatment.
ORAVI is a novel once-daily mucoadhesive tablet formulation of the antifungal agent miconazole for the treatment of oropharyngeal candidiasis (OPC), a condition that occurs frequently in immunocompromised patients due to HIV, malignant tumours, etc.
SCYNEXIS provided a year-end update and 2019 development plans for ibrexafungerp, an investigational antifungal agent and the first representative of a novel class of structurally-distinct glucan synthase inhibitors, triterpenoids.
Summary: An antibacterial and antifungal agent found in hand soaps and toothpastes can potentially cause colon cancer