In an experiment with rodents (Mastomys coucha) the crude extract from stem of Lantana by oral route shows antifilarial
efficacy (Mishra et al., 2007) by killing 40% of adult Brugia malayi parasites and sterilizing three fourth of the female worms.
Therefore, global research efforts were more focused on getting antifilarial
drugs which could help to reduce the burden of the disease.
The following groups were characterized: (1) control (4 cases): symptomless individuals from which living AWs nonsensitive to antifilarial
treatment were removed [17-20]; (2) patients with dead AWs in the PL (1 case); (3) acute filarial hydrocele (3 cases): patients with fluid accumulation in the tunica vaginalis cavity which appears within a few days after a nodule formation and resolves spontaneously up to 18 months ; (4) filaricele (20 cases): patients with chronic accumulation in the tunica vaginalis cavity of fluid composed of a combination, in different proportion, of transudate and nonmilky lymph from ruptured dilated lymphatic vessels .
The synthesis of chalcone has drawn much attentions due to the presence of its [alpha], [beta]- unsaturated ketone moieties which contributes to various biological activities such as antimalaria , anticancer , antiprotozoal, anti-inflammatory, antibacterial, antifilarial
, anticonvulsant , antifungal, insect antifeedant, antimutagenic , and antioxidant [24, 25].
DEC has been used as an antifilarial
drug since 1947.
perstans nematodes raises questions about treatment (1) because of poor responses to standard antifilarial
drugs and limited findings from controlled trials.
Firstly, serological tests that are considered a better alternative than microscopic methods have been developed in two approaches: (i) immunoenzymatic technique detecting antifilarial
antibodies (IgG4) that are usually high in patients with active filarial infection [39, 40]; (ii) immunochromatographic tests detecting circulating filarial antigen .
Ivermectin, an antifilarial
drug, is the essential tool in eradicating river blindness from the developing world.
Lead Molecules Isolated from Trachyspermum ammi.
Improved canine chemoprophylaxis may require combinations or sequential dosages of the macrocyclic lactones including ivermectin, moxidectin, selamectin, and milbemycin oxime; or by adding another effective antifilarial
medication, such as melarsomine dihydrochloride to the prophylactic regimen.
The present study has identified Sd30 (Sd--Setaria digitata, 30-MW-30 kDa), an allergenic fraction purified from Setaria digitata (a cattle filarial parasite) that can detect the antifilarial
(Wuchereria bancrofti) antibodies (IgM and IgG4) produced during the acute/chronic manifestation of extra lymphatic pathology like arthritis caused by W.
In a report of 350 men with filarial genital lymphedema, all patients underwent surgical excision of lymphedematous tissue with split thickness skin graft to the penile shaft and scrotal reconstruction with advancement flaps; this report yielded an overall complication rate of 19.4%.[sup.8] This included a 10.2% rate of infection, 8.2% rate of hematoma and 7.3% recurrence of lymphedema, which the authors attributed to discontinuation of antifilarial
drugs.[sup.8] In one of our patients, a postoperative infection occurred, which was successfully treated with debridement, antibiotics and a wound vac.