Experimental studies indicate that TNF-alpha may have both profibrotic and antifibrotic
effects; the imbalance between these two roles may trigger fibrosis or stable ILD in vulnerable individuals, but further studies are needed to confirm this hypothesis (36).
Lanifibranor, Inventiva's lead product candidate, is an orally-available small molecule that acts to induce antifibrotic
, anti-inflammatory and beneficial metabolic changes in the body by activating all three peroxisome proliferator activated receptor ('PPAR') isoforms, which are well characterized nuclear receptor proteins that regulate gene expression.
Recent changes in the competitive landscape and the insights we've collected from physicians, payers and patients have reinforced our conviction that OCA, if approved, is in a unique position to address the significant unmet medical need for an antifibrotic
therapy intended to treat this serious disease."
Boehringer Ingelheim has developed OFEV (nintedanib), an antifibrotic
drug shown to slow disease progression by reducing lung function decline and currently approved for the treatment of IPF in more than 70 countries around the world including the US, the EU and Japan.
These interventions had multiple overlapping pharmacological actions including antioxidant, antiviral, anti-inflammatory and antifibrotic
Hemodynamic and antifibrotic
effects of losartan in rats with liver fibrosis and/or portal hypertension.
(4) In addition to anti-inflammatory properties, cannabis and cannabinoids have been associated with antipruritic, antineoplastic, antifibrotic
, analgesic, antiemetic, and antiwasting effects.
and anti-inflammatory properties of melatonin on human gingival fibroblasts in vitro.
MMC adopted by the pharma industry for antifibrotic
screening: production of stem cell matrix, and tuning the microarchitecture of bioprinted collagen hydrogels
effect of a combination of verapamil and silymarin in rat-induced liver fibrosis.
MSCs also modify tissue healing through proangiogenic, antifibrotic
, and antiapoptotic pathways.3