Prometic Life Sciences announced the publication in the American Journal of Pathology, the official journal of the American Society of Investigational Pathology, of the novel antifibrotic
mechanism of action of its small molecule lead drug candidate, PBI-4050.
The paper 'Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic
cell phenotype' is published in the journal Science Signalling.
In chronic hepatitis C patients candesartan in standard doses exerted an antifibrotic
effect detected by measuring the following noninvasive fibrotic indexes: Forns index, the AST to platelet ratio index and FibroIndex" (25).
Decorin, an antifibrotic
agent, regulates collagen fibrils and is mostly expressed by fibroblasts, myocytes, and smooth muscle cells.
Studies have clearly documented that early stages of fibrosis are reversible either by removal of the specific stimulus or by treatment with antifibrotic
medications, whereas late stages, progressing to cirrhosis, are less reversible.
23] Astragaloside is a main active ingredient in traditional Chinese medicine and acts both as an anti-inflammatory and antifibrotic
agent,, while salvianolic acid A has been shown to have cardiovascular protective effects.
Accurate diagnosis of IPF has become even more critical in the last few years, with the recognition of the adverse effects of prednisone, azathioprine, and N-acetylcysteine triple therapy in IPF, (5) and US Food and Drug Administration approval in 2014 of the targeted antifibrotic
agents pirfenidone and nintedanib that slow disease progression in IPF.
Another study that included 42 dogs showed that miR-133 and miR-30, which are antifibrotic
markers, were underexpressed in dogs with atrial fibrillation (LI et al.
From a NASH perspective, it improves insulin sensitivity and, by doing that, decreases lipogenesis, and it also has been shown to have some antifibrotic
sup], Estrogen also exerts antifibrotic
effects by both inhibiting collagen synthesis and enhancing its degradation.
This first-generation designer NP retains the antifibrotic
, antiproliferative, and antihypertrophic effects and venodilatation of CNP via pGC-B, as well as natriuretic and diuretic and aldosterone-suppressing effects of DNP via pGC-A.
Herein we propose to develop a cell-based assay for high-throughput screening of new antifibrotic
therapeutics, which will accelerate fibrosis drug development.