antifibrinolytics

antifibrinolytics

Drugs used to treat excessive bleeding as in menorrhagia or to help in the control of bleeding during surgery. Examples are tranexamic acid (Cyklokapron) and aprotinin (Trasylol).
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Most commonly used medications that contributed to ADRs were hematinics - 42% (ferrous sulfate + iron sucrose), followed by antimicrobials (31%), analgesics (9%), hormones (6%), uterine stimulants (5%), and miscellaneous such as antifibrinolytics (3%), uterine relaxants (2%), mineral (1%), and antihypertensive drugs (1%) [Figure 2].
Treatment options include iron supplementation, combined oral contraceptives (COCs), progesterone, nonsteroidal anti-inflammatory drugs (NSAIDs), antifibrinolytics, desmopressin and GnRH analogues.
After controlling for the factors that might have effects on operative blood loss other than types of antifibrinolytics used, such as levels fused, total operative time, osteotomies performed and surgeon variability, AM showed no effect in reduction of operative blood loss when compared with NA group, however, TXA was found to be significantly effective.
During the admission period, his condition was complicated by septicemia and disseminated intravascular coagulation, which were managed by broad-spectrum intravenous antibiotics according to culture and sensitivity and supportive treatment (anticoagulants, blood components, and antifibrinolytics).
Aprotinin was one of the most effective drugs of this class, but its use was discouraged by the Food and Drug Administration (FDA) after studies like international multicenter aprotonin graft patency experience (IMAGE) and blood conservation using antifibrinolytics randomized trial (BART) in high-risk cardiac surgery.4,12 In the IMAGE trial, use of aprotonin led to a statistically significant difference in graft occlusion rate against their controls when the results were adjusted contrary to the risks known to be associated with graft failure.4 According to BART investigators, the risks of aprotinin far exceeded its benefits.
We are limited to the use of 17[alpha]-alkylated androgens such as danazol and the antifibrinolytics such as tranexamic acid.
For example, lysine analogs are used as antifibrinolytics to stop bleeds, whereas an arginine analog is used as an antithrombotic agent.
For more severe cases, desmopressin (DDAVP) or antifibrinolytics may be used to control mild bleeding episodes, while platelet transfusion remains a primary option to address severe bleeding or prepare patients for surgeries with a high bleeding risk, such a neurosurgery.
The use of antifibrinolytics (e.g., tranexamic acid) or androgens (e.g.
Pharmaceutical agents such as propranolol, octreotide, corticosteroids, interferon alpha, thalidomide, antifibrinolytics, and most recently sirolimus have also been utilized.
Antifibrinolytics help in reduction of blood loss during obstetric surgeries and other haemorrhages.
On the basis of Drug Class the report includes segments such as Plasma-derived Coagulation Factor Concentrates, Recombinant Coagulation Factor Concentrates, Desmopressin, Antifibrinolytics, Fibrin Sealants & others.