Experimental studies have demonstrated that vagal stimulation has an
antifibrillatory effect and has proven to be beneficial in animal models of heart failure [6, 7].
Although verapamil can have potent
antifibrillatory effects in ischemia models [11, 22-25], presumably by decreasing myocardial ischemia, the instantaneous nature of VF in commotio cordis argues against ischemia as a cause of VF.
Fedida, "Vernakalant (RSD1235): a novel, atrial-selective
antifibrillatory agent," Expert Opinion on Investigational Drugs, vol.
In this sense, more recently, experimental studies have demonstrated that vagal stimulation promoted an
antifibrillatory effect and reduced mortality rate in animal models of HF [37, 38].
(53.) Haverkamp W, Hindricks G, Ketellar T, et al : Prophylactic antiarrhythmic and
antifibrillatory effects of intravenous magnesium sulfate during myocardial ischemia Eur Heart J 9 : 228, 1988
Antihypertensive agents such as angiotensin converting enzyme inhibitors and angiotensin receptor blockers have
antifibrillatory and antifibrotic actions via inhibition of angiotensin II.
He said one explanation for the conflicting findings could be that fish oil may have profibrillatory effects in healthy individuals but
antifibrillatory effects in subjects with preexisting cardiovascular disease (CVD).