Experimental studies have demonstrated that vagal stimulation has an antifibrillatory
effect and has proven to be beneficial in animal models of heart failure [6, 7].
Although verapamil can have potent antifibrillatory
effects in ischemia models [11, 22-25], presumably by decreasing myocardial ischemia, the instantaneous nature of VF in commotio cordis argues against ischemia as a cause of VF.
Fedida, "Vernakalant (RSD1235): a novel, atrial-selective antifibrillatory
agent," Expert Opinion on Investigational Drugs, vol.
In this sense, more recently, experimental studies have demonstrated that vagal stimulation promoted an antifibrillatory
effect and reduced mortality rate in animal models of HF [37, 38].
(53.) Haverkamp W, Hindricks G, Ketellar T, et al : Prophylactic antiarrhythmic and antifibrillatory
effects of intravenous magnesium sulfate during myocardial ischemia Eur Heart J 9 : 228, 1988
Antihypertensive agents such as angiotensin converting enzyme inhibitors and angiotensin receptor blockers have antifibrillatory
and antifibrotic actions via inhibition of angiotensin II.
He said one explanation for the conflicting findings could be that fish oil may have profibrillatory effects in healthy individuals but antifibrillatory
effects in subjects with preexisting cardiovascular disease (CVD).