In 21 (55.3%) SUDEP cases, toxicological analysis revealed no
antiepileptic agent, while it was not performed in two cases.
Participants in the open-label levetiracetam study had previously failed on between one and three preventive drugs and had taken no more than one
antiepileptic agent. They were placed on 250 mg/day of levetiracetam, with the dosage being bumped up by 250 mg/day every 5 days until reaching 1,000 mg once daily.
Concomitant
antiepileptic agents can be reduced by approximately 25% every 2 weeks.
In addition to Lennox-Gastaut syndrome (LGS) treatment Inovelon(R)/Banzel(R), Eisai currently markets Zonegran(R) (sodium/calcium channel blocking
antiepileptic agent marketed in Europe, the United States and Asia under license from the originator, Dainippon Sumitomo Pharma Co., Ltd.) and Zebinix(R) (voltage-dependent sodium channel-blocking
antiepileptic agent marketed in Europe under license from the originator, BIAL-Portela & Ca S.A.) for the treatment of partial-onset seizures, and anticonvulsant agent Fostoin(R) (water-soluble pro-drug of phenytoin marketed in Japan with co-promotion partner Nobelpharma Co., Ltd.) for use in the treatment of conditions such as status epilepticus.
Also garnering attention were open-label studies of headache prevention utilizing botulinum toxin type A injections, the
antiepileptic agent topiramate, and the atypical antipsychotic agent quetiapine.
The Group's revenue increased overall primarily due to the significant growth of the anticancer agent Lenvima mainly accompanying the acquisition of approval for use in the treatment of hepatocellular carcinoma in Japan, as well as the steady growth of fully human anti-TNF-[alpha] monoclonal antibody Humira and
antiepileptic agent Fycompa, absorbing the impact of drug pricing revision in Japan and the launch of generic versions of antiemetic agent Aloxi in the United States.
announced today that it has received manufacturing and marketing authorization in Japan from the Japanese Ministry of Health, Labour and Welfare (MHLW) for
antiepileptic agent Inovelon(R) (rufinamide), approving the drug as an adjunctive therapy to other antiepileptic drugs (AEDs) in the treatment of Lennox-Gastaut syndrome (LGS), a rare disorder.
announced today that it has submitted a marketing authorization application to Japan s Ministry of Health, Labour and Welfare (MHLW) for rufinamide (generic name), an
antiepileptic agent developed by the company in Japan.
The
antiepileptic agent was employed as add-on therapy in 32 patients with refractory tics and as monotherapy in 7.
(EML) situated within the company's European Knowledge Centre (EKC), has received a license (marketing authorization type II variation: addition of manufacturing site) from the European regulatory authorities for solid dose manufacturing of the
antiepileptic agent Fycompa(R) (perampanel), a first-in-class AMPA receptor antagonist discovered and developed in-house, at its Hatfield production plant.
announced today that the Ministry of Health and Social Development of the Russian Federation has approved the
antiepileptic agent Zonegran(R) (zonisamide) as an adjunctive therapy in the treatment of adult epilepsy patients with partial seizures.
Sales grew in the North America segment as
antiepileptic agent APTIOM[R] and other mainstay products continued to perform briskly, while sales of atypical antipsychotic agent LATUDA[R], which is one of the primary sources of revenue for the Group, remained strong.
